Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Alaa I Alyahya; Sarah J Charman; Nduka C Okwose; Amy S Fuller; Christopher Eggett; Peter Luke; Kristian Bailey; Guy A MacGowan; Djordje G Jakovljevic

doi:10.1111/cpf.12840

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Alaa I Alyahya, Sarah J Charman, Nduka C Okwose, Amy S Fuller, Christopher Eggett, Peter Luke, Kristian Bailey, Guy A MacGowan, Djordje G Jakovljevic

Centre for Health and Life Sciences

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Abstract

Objectives: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.

Methods: Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m²) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m ²) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.

Results: Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms², p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m², p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m²cm⁻⁵, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.

Conclusions: Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.

Original language	English
Pages (from-to)	421-430
Number of pages	10
Journal	Clinical Physiology and Functional Imaging
Volume	43
Issue number	6
Early online date	9 Jun 2023
DOIs	https://doi.org/10.1111/cpf.12840
Publication status	Published - Nov 2023

Bibliographical note

This is the peer reviewed version of the following article: Alyahya, AI, Charman, SJ, Okwose, NC, Fuller, AS, Eggett, C, Luke, P, Bailey, K, MacGowan, GA & Jakovljevic, DG 2023, 'Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy', Clinical Physiology and Functional Imaging, vol. 43, no. 6, pp. 421-430., which has been published in final form at https://doi.org/10.1111/cpf.12840. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Funder

This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement no. 777204. Miss Alaa I. Alyahya is supported by the Saudi Arabia Government and Imam Abdulrahman Bin Faisal University via an international doctoral scholarship.

Keywords

hypertrophic cardiomyopathy
heart rate variability
frequency domain
haemodynamic function
autonomic function

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Jakovljevic2023AAMAccepted author manuscript, 949 KB

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title = "Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy",

abstract = "Objectives: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM. Methods: Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m 2) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.Results: Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm−5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.Conclusions: Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.",

keywords = "hypertrophic cardiomyopathy, heart rate variability, frequency domain, haemodynamic function, autonomic function",

author = "Alyahya, {Alaa I} and Charman, {Sarah J} and Okwose, {Nduka C} and Fuller, {Amy S} and Christopher Eggett and Peter Luke and Kristian Bailey and MacGowan, {Guy A} and Jakovljevic, {Djordje G}",

note = "This is the peer reviewed version of the following article: Alyahya, AI, Charman, SJ, Okwose, NC, Fuller, AS, Eggett, C, Luke, P, Bailey, K, MacGowan, GA & Jakovljevic, DG 2023, 'Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy', Clinical Physiology and Functional Imaging, vol. 43, no. 6, pp. 421-430., which has been published in final form at https://doi.org/10.1111/cpf.12840. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley{\textquoteright}s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This document is the author{\textquoteright}s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it. ",

year = "2023",

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T1 - Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

AU - Alyahya, Alaa I

AU - Charman, Sarah J

AU - Okwose, Nduka C

AU - Fuller, Amy S

AU - Eggett, Christopher

AU - Luke, Peter

AU - Bailey, Kristian

AU - MacGowan, Guy A

AU - Jakovljevic, Djordje G

N1 - This is the peer reviewed version of the following article: Alyahya, AI, Charman, SJ, Okwose, NC, Fuller, AS, Eggett, C, Luke, P, Bailey, K, MacGowan, GA & Jakovljevic, DG 2023, 'Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy', Clinical Physiology and Functional Imaging, vol. 43, no. 6, pp. 421-430., which has been published in final form at https://doi.org/10.1111/cpf.12840. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

PY - 2023/11

Y1 - 2023/11

N2 - Objectives: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM. Methods: Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m 2) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.Results: Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm−5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.Conclusions: Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.

AB - Objectives: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM. Methods: Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m 2) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.Results: Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm−5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.Conclusions: Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.

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KW - heart rate variability

KW - frequency domain

KW - haemodynamic function

KW - autonomic function

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Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

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