Healthy Eating Index-2015 as a Predictor of Ulcerative Colitis Risk in a Case–Control Cohort

Jamal Rahmani, Hamed Kord Varkaneh, Paul Ryan, Meysem Zarezadeh, Samaneh Rashvand, Cain Clark, Andrew S Day, Azita Hekmatdoost

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)
    52 Downloads (Pure)


    Objective: There is compelling clinical evidence implicating certain dietary components in the development and clinical course of progression in ulcerative colitis (UC). This study aimed to assess whether any association exists between ulcerative colitis and scores on a healthy eating index. Methods: In this case-control study patients with UC were recruited and assessed together with healthy controls. The participants completed a validated 168-item food frequency questionnaire, the results of which were subsequently used to generate individual healthy eating index (HEI-2015) scores. Results: Altogether 58 patients with UC and 123 healthy controls were recruited. After controlling for confounding factors, participants who were in the highest quartile of the HEI-2015 had a 66% lower odds ratio (OR) of UC than the lowest quartile (OR = 0.34, 95% confidence interval 0.12-0.96). Conclusion: HEI-2015 was associated with UC in this cohort. Further elucidation of the role of key dietary elements is now warranted.

    Original languageEnglish
    Pages (from-to)649-655
    Number of pages7
    JournalJournal of Digestive Diseases
    Issue number12
    Early online date21 Oct 2019
    Publication statusPublished - 1 Dec 2019

    Bibliographical note

    This is the peer reviewed version of the following article: Rahmani, Jamal et al. "Healthy Eating Index-2015 as a Predictor of Ulcerative Colitis Risk in a Case–Control Cohort". Journal of Digestive Diseases. 2019, 20(12). 649-655. which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

    Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.


    • Healthy Eating Index
    • diet
    • inflammatory bowel diseases
    • ulcerative colitis

    ASJC Scopus subject areas

    • Gastroenterology


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