Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence

Giorgio  Broccia; Jonathan Carter; Cansu  Ozsin-Ozler; Federico  Meloni; Ilaria  Pilia; Giannina  Satta; Giulio  Murgia; Marcello  Campagna; Pierluigi  Cocco

doi:10.1136/bmjopen-2020-037163

Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence

Giorgio Broccia
, Jonathan Carter
, Cansu Ozsin-Ozler
, Federico Meloni
, Ilaria Pilia
, Giannina Satta
, Giulio Murgia
, Marcello Campagna
, Pierluigi Cocco

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

66 Downloads (Pure)

Abstract

Objectives To explore the time trend and geographical
distribution of childhood leukaemia incidence over the
territory of the Italian region of Sardinia. Setting All hospitals departments, diagnostic centres and social security agencies in Sardinia were regularly screened in 1974–2003 to identify, register and review the diagnoses of incident cases of haematological
malignancies (HM).
Participants The whole child population aged 0–14 resident in Sardinia. Primary and secondary outcome measures Incidence and time trend of childhood HM and childhood acute lymphoblastic leukaemia (ALL) over the study period, and use of Bayesian methods to plot the probability of areas with excess incidence on the regional map.
Results Overall, 675 HM cases, including 378 ALL cases, occurred among children aged 0–14 years resident in Sardinia in 1974–2003, with an incidence rate of 6.97×10- 5 (95% CI 6.47 to 7.51) and 3.85×10-5 (95% CI 3.48 to 4.26), respectively. Incidence of HM and ALL showed an upward trend along the study period especially among females. Three communes out of the 356 existing in 1974,
namely Ittiri, Villa San Pietro and Carbonia, stand out as areas with excess incidence of HM and ALL in particular and another, Carloforte, for ALL only.
Conclusions Our results might serve as convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants in the areas at risk.

Original language	English
Article number	e037163
Number of pages	7
Journal	BMJ Open
Volume	10
Issue number	11
DOIs	https://doi.org/10.1136/bmjopen-2020-037163
Publication status	Published - 3 Nov 2020

Bibliographical note

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

epidemiology
leukaemia
paediatric oncology
public health

ASJC Scopus subject areas

General Medicine

Access to Document

10.1136/bmjopen-2020-037163Licence: CC BY-NC

PublishedFinal published version, 1.68 MBLicence: CC BY

Cite this

@article{8db528bba9954396810bf3d0b26231c0,

title = "Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence",

abstract = "Objectives To explore the time trend and geographical distribution of childhood leukaemia incidence over the territory of the Italian region of Sardinia. Setting All hospitals departments, diagnostic centres and social security agencies in Sardinia were regularly screened in 1974–2003 to identify, register and review the diagnoses of incident cases of haematological malignancies (HM). Participants The whole child population aged 0–14 resident in Sardinia. Primary and secondary outcome measures Incidence and time trend of childhood HM and childhood acute lymphoblastic leukaemia (ALL) over the study period, and use of Bayesian methods to plot the probability of areas with excess incidence on the regional map. Results Overall, 675 HM cases, including 378 ALL cases, occurred among children aged 0–14 years resident in Sardinia in 1974–2003, with an incidence rate of 6.97×10- 5 (95\% CI 6.47 to 7.51) and 3.85×10-5 (95\% CI 3.48 to 4.26), respectively. Incidence of HM and ALL showed an upward trend along the study period especially among females. Three communes out of the 356 existing in 1974, namely Ittiri, Villa San Pietro and Carbonia, stand out as areas with excess incidence of HM and ALL in particular and another, Carloforte, for ALL only. Conclusions Our results might serve as convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants in the areas at risk.",

keywords = "epidemiology, leukaemia, paediatric oncology, public health",

author = "Giorgio Broccia and Jonathan Carter and Cansu Ozsin-Ozler and Federico Meloni and Ilaria Pilia and Giannina Satta and Giulio Murgia and Marcello Campagna and Pierluigi Cocco",

note = "This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.",

year = "2020",

month = nov,

day = "3",

doi = "10.1136/bmjopen-2020-037163",

language = "English",

volume = "10",

journal = "BMJ Open",

issn = "2044-6055",

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TY - JOUR

T1 - Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence

AU - Broccia, Giorgio

AU - Carter, Jonathan

AU - Ozsin-Ozler, Cansu

AU - Meloni, Federico

AU - Pilia, Ilaria

AU - Satta, Giannina

AU - Murgia, Giulio

AU - Campagna, Marcello

AU - Cocco, Pierluigi

N1 - This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

PY - 2020/11/3

Y1 - 2020/11/3

N2 - Objectives To explore the time trend and geographical distribution of childhood leukaemia incidence over the territory of the Italian region of Sardinia. Setting All hospitals departments, diagnostic centres and social security agencies in Sardinia were regularly screened in 1974–2003 to identify, register and review the diagnoses of incident cases of haematological malignancies (HM). Participants The whole child population aged 0–14 resident in Sardinia. Primary and secondary outcome measures Incidence and time trend of childhood HM and childhood acute lymphoblastic leukaemia (ALL) over the study period, and use of Bayesian methods to plot the probability of areas with excess incidence on the regional map. Results Overall, 675 HM cases, including 378 ALL cases, occurred among children aged 0–14 years resident in Sardinia in 1974–2003, with an incidence rate of 6.97×10- 5 (95% CI 6.47 to 7.51) and 3.85×10-5 (95% CI 3.48 to 4.26), respectively. Incidence of HM and ALL showed an upward trend along the study period especially among females. Three communes out of the 356 existing in 1974, namely Ittiri, Villa San Pietro and Carbonia, stand out as areas with excess incidence of HM and ALL in particular and another, Carloforte, for ALL only. Conclusions Our results might serve as convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants in the areas at risk.

AB - Objectives To explore the time trend and geographical distribution of childhood leukaemia incidence over the territory of the Italian region of Sardinia. Setting All hospitals departments, diagnostic centres and social security agencies in Sardinia were regularly screened in 1974–2003 to identify, register and review the diagnoses of incident cases of haematological malignancies (HM). Participants The whole child population aged 0–14 resident in Sardinia. Primary and secondary outcome measures Incidence and time trend of childhood HM and childhood acute lymphoblastic leukaemia (ALL) over the study period, and use of Bayesian methods to plot the probability of areas with excess incidence on the regional map. Results Overall, 675 HM cases, including 378 ALL cases, occurred among children aged 0–14 years resident in Sardinia in 1974–2003, with an incidence rate of 6.97×10- 5 (95% CI 6.47 to 7.51) and 3.85×10-5 (95% CI 3.48 to 4.26), respectively. Incidence of HM and ALL showed an upward trend along the study period especially among females. Three communes out of the 356 existing in 1974, namely Ittiri, Villa San Pietro and Carbonia, stand out as areas with excess incidence of HM and ALL in particular and another, Carloforte, for ALL only. Conclusions Our results might serve as convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants in the areas at risk.

KW - epidemiology

KW - leukaemia

KW - paediatric oncology

KW - public health

UR - https://www.scopus.com/pages/publications/85095675569

U2 - 10.1136/bmjopen-2020-037163

DO - 10.1136/bmjopen-2020-037163

M3 - Article

SN - 2044-6055

VL - 10

JO - BMJ Open

JF - BMJ Open

IS - 11

M1 - e037163

ER -

Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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