Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence

Giorgio Broccia, Jonathan Carter, Cansu Ozsin-Ozler, Federico Meloni, Ilaria Pilia, Giannina Satta, Giulio Murgia, Marcello Campagna, Pierluigi Cocco

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
36 Downloads (Pure)


Objectives To explore the time trend and geographical
distribution of childhood leukaemia incidence over the
territory of the Italian region of Sardinia. Setting All hospitals departments, diagnostic centres and social security agencies in Sardinia were regularly screened in 1974–2003 to identify, register and review the diagnoses of incident cases of haematological
malignancies (HM).
Participants The whole child population aged 0–14 resident in Sardinia. Primary and secondary outcome measures Incidence and time trend of childhood HM and childhood acute lymphoblastic leukaemia (ALL) over the study period, and use of Bayesian methods to plot the probability of areas with excess incidence on the regional map.
Results Overall, 675 HM cases, including 378 ALL cases, occurred among children aged 0–14 years resident in Sardinia in 1974–2003, with an incidence rate of 6.97×10- 5 (95% CI 6.47 to 7.51) and 3.85×10-5 (95% CI 3.48 to 4.26), respectively. Incidence of HM and ALL showed an upward trend along the study period especially among females. Three communes out of the 356 existing in 1974,
namely Ittiri, Villa San Pietro and Carbonia, stand out as areas with excess incidence of HM and ALL in particular and another, Carloforte, for ALL only.
Conclusions Our results might serve as convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants in the areas at risk.
Original languageEnglish
Article numbere037163
Number of pages7
JournalBMJ Open
Issue number11
Publication statusPublished - 3 Nov 2020

Bibliographical note

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.


  • epidemiology
  • leukaemia
  • paediatric oncology
  • public health

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Haemolymphatic cancer among children in Sardinia, Italy: 1974–2003 incidence'. Together they form a unique fingerprint.

Cite this