Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease: A preliminary study

Thanapong Chaichana, Zhonghua Sun, James Jewkes

    Research output: Chapter in Book/Report/Conference proceedingConference proceedingpeer-review

    3 Citations (Scopus)

    Abstract

    The aim of this study is to investigate the hemodynamic effect of the angulations in the left coronary bifurcation on subsequent development of coronary artery disease. Eight 3D left coronary artery models were generated based on the anatomical details and simulated for numerical analysis. The angulations at the left coronary bifurcation were simulated with angles ranging from 120°, 105°, 90°, 75°, 60°, 45°, 30° to 15°. Computational fluid dynamic models were produced for analysis of flow velocity, wall pressure and wall shear stress. Our results showed that wide angled models produced low wall shear stress and high wall pressure at the left coronary bifurcation regions, whereas, flow pattern was more smooth and laminar with narrow angled models than those with wide angle models. Our analysis indicates the flow-field correlation between coronary angulation and development of atherosclerosis. Future studies are required to analyse the realistic coronary models from patients' data with different degree of coronary stenosis.

    Original languageEnglish
    Title of host publicatione-Science 2010
    Subtitle of host publicationSixth IEEE International Conference on e-Science: Proceedings of Workshops
    Place of PublicationNew Jersey
    PublisherIEEE
    Pages39-43
    Number of pages5
    ISBN (Electronic) 978-0-7695-4295-9
    ISBN (Print)9780769542959, 978-1-4244-8988-6
    DOIs
    Publication statusPublished - 20 Jan 2011
    EventIEEE International Conference on e-Science Workshops, - Queensland University of Technology, Brisbane, QLD, Australia
    Duration: 7 Dec 201010 Dec 2010
    Conference number: 6
    http://escience2010.org/ (Link to conference website)

    Conference

    ConferenceIEEE International Conference on e-Science Workshops,
    Abbreviated titlee-ScienceW 2010
    Country/TerritoryAustralia
    CityBrisbane, QLD
    Period7/12/1010/12/10
    Internet address

    Keywords

    • Angulation
    • Blood flow
    • Coronary artery disease
    • Flow velocity
    • Plaque
    • Simulation

    ASJC Scopus subject areas

    • Computer Networks and Communications

    Fingerprint

    Dive into the research topics of 'Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease: A preliminary study'. Together they form a unique fingerprint.

    Cite this