Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease: A preliminary study

Thanapong Chaichana; Zhonghua Sun; James Jewkes

doi:10.1109/eScienceW.2010.16

Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease: A preliminary study

Thanapong Chaichana, Zhonghua Sun, James Jewkes

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding › peer-review

3 Citations (Scopus)

Abstract

The aim of this study is to investigate the hemodynamic effect of the angulations in the left coronary bifurcation on subsequent development of coronary artery disease. Eight 3D left coronary artery models were generated based on the anatomical details and simulated for numerical analysis. The angulations at the left coronary bifurcation were simulated with angles ranging from 120°, 105°, 90°, 75°, 60°, 45°, 30° to 15°. Computational fluid dynamic models were produced for analysis of flow velocity, wall pressure and wall shear stress. Our results showed that wide angled models produced low wall shear stress and high wall pressure at the left coronary bifurcation regions, whereas, flow pattern was more smooth and laminar with narrow angled models than those with wide angle models. Our analysis indicates the flow-field correlation between coronary angulation and development of atherosclerosis. Future studies are required to analyse the realistic coronary models from patients' data with different degree of coronary stenosis.

Original language	English
Title of host publication	e-Science 2010
Subtitle of host publication	Sixth IEEE International Conference on e-Science: Proceedings of Workshops
Place of Publication	New Jersey
Publisher	IEEE
Pages	39-43
Number of pages	5
ISBN (Electronic)	978-0-7695-4295-9
ISBN (Print)	9780769542959, 978-1-4244-8988-6
DOIs	https://doi.org/10.1109/eScienceW.2010.16
Publication status	Published - 20 Jan 2011
Event	IEEE International Conference on e-Science Workshops, - Queensland University of Technology, Brisbane, QLD, Australia Duration: 7 Dec 2010 → 10 Dec 2010 Conference number: 6 http://escience2010.org/ (Link to conference website)

Conference

Conference	IEEE International Conference on e-Science Workshops,
Abbreviated title	e-ScienceW 2010
Country/Territory	Australia
City	Brisbane, QLD
Period	7/12/10 → 10/12/10
Internet address	http://escience2010.org/ (Link to conference website)

Keywords

Angulation
Blood flow
Coronary artery disease
Flow velocity
Plaque
Simulation

ASJC Scopus subject areas

Computer Networks and Communications

Access to Document

10.1109/eScienceW.2010.16

Cite this

Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease : A preliminary study. / Chaichana, Thanapong; Sun, Zhonghua; Jewkes, James.

e-Science 2010: Sixth IEEE International Conference on e-Science: Proceedings of Workshops. New Jersey : IEEE, 2011. p. 39-43 5693139.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding › peer-review

Chaichana, T, Sun, Z & Jewkes, J 2011, Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease: A preliminary study. in e-Science 2010: Sixth IEEE International Conference on e-Science: Proceedings of Workshops., 5693139, IEEE, New Jersey, pp. 39-43, IEEE International Conference on e-Science Workshops, , Brisbane, QLD, Australia, 7/12/10. https://doi.org/10.1109/eScienceW.2010.16

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abstract = "The aim of this study is to investigate the hemodynamic effect of the angulations in the left coronary bifurcation on subsequent development of coronary artery disease. Eight 3D left coronary artery models were generated based on the anatomical details and simulated for numerical analysis. The angulations at the left coronary bifurcation were simulated with angles ranging from 120°, 105°, 90°, 75°, 60°, 45°, 30° to 15°. Computational fluid dynamic models were produced for analysis of flow velocity, wall pressure and wall shear stress. Our results showed that wide angled models produced low wall shear stress and high wall pressure at the left coronary bifurcation regions, whereas, flow pattern was more smooth and laminar with narrow angled models than those with wide angle models. Our analysis indicates the flow-field correlation between coronary angulation and development of atherosclerosis. Future studies are required to analyse the realistic coronary models from patients' data with different degree of coronary stenosis.",

keywords = "Angulation, Blood flow, Coronary artery disease, Flow velocity, Plaque, Simulation",

author = "Thanapong Chaichana and Zhonghua Sun and James Jewkes",

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N2 - The aim of this study is to investigate the hemodynamic effect of the angulations in the left coronary bifurcation on subsequent development of coronary artery disease. Eight 3D left coronary artery models were generated based on the anatomical details and simulated for numerical analysis. The angulations at the left coronary bifurcation were simulated with angles ranging from 120°, 105°, 90°, 75°, 60°, 45°, 30° to 15°. Computational fluid dynamic models were produced for analysis of flow velocity, wall pressure and wall shear stress. Our results showed that wide angled models produced low wall shear stress and high wall pressure at the left coronary bifurcation regions, whereas, flow pattern was more smooth and laminar with narrow angled models than those with wide angle models. Our analysis indicates the flow-field correlation between coronary angulation and development of atherosclerosis. Future studies are required to analyse the realistic coronary models from patients' data with different degree of coronary stenosis.

AB - The aim of this study is to investigate the hemodynamic effect of the angulations in the left coronary bifurcation on subsequent development of coronary artery disease. Eight 3D left coronary artery models were generated based on the anatomical details and simulated for numerical analysis. The angulations at the left coronary bifurcation were simulated with angles ranging from 120°, 105°, 90°, 75°, 60°, 45°, 30° to 15°. Computational fluid dynamic models were produced for analysis of flow velocity, wall pressure and wall shear stress. Our results showed that wide angled models produced low wall shear stress and high wall pressure at the left coronary bifurcation regions, whereas, flow pattern was more smooth and laminar with narrow angled models than those with wide angle models. Our analysis indicates the flow-field correlation between coronary angulation and development of atherosclerosis. Future studies are required to analyse the realistic coronary models from patients' data with different degree of coronary stenosis.

KW - Angulation

KW - Blood flow

KW - Coronary artery disease

KW - Flow velocity

KW - Plaque

KW - Simulation

U2 - 10.1109/eScienceW.2010.16

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ER -

Haemodynamic effect of coronary angulations on subsequent development of coronary artery disease: A preliminary study

Abstract

Conference

Keywords

ASJC Scopus subject areas

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