Haemodynamic determinants of quality of life in chronic heart failure

Serlie Fatrin; Nduka C Okwose; Kristian Bailey; Lazar Velicki; Dejana Popovic; Arsen Ristic; Petar M Seferovic; Guy A MacGowan; Djordje G Jakovljevic

doi:10.1186/s12872-022-02829-w

Haemodynamic determinants of quality of life in chronic heart failure

Serlie Fatrin, Nduka C Okwose, Kristian Bailey, Lazar Velicki, Dejana Popovic, Arsen Ristic, Petar M Seferovic, Guy A MacGowan, Djordje G Jakovljevic

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Abstract

BACKGROUND: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure.

METHODS: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire.

RESULTS: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O 2 consumption (r = - 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = - 0.08, p = 0.60).

CONCLUSION: Peak O 2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.

Original language	English
Article number	412
Number of pages	6
Journal	BMC Cardiovascular Disorders
Volume	22
Issue number	1
Early online date	16 Sept 2022
DOIs	https://doi.org/10.1186/s12872-022-02829-w
Publication status	E-pub ahead of print - 16 Sept 2022

Bibliographical note

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Funder

This study is supported by Research Councils’ UK Centre for Ageing and Vitality at Newcastle University [Grant Number L016354]. NO, LV, DP, AR, GAM, and DGJ are supported by the European Horizon 2020 Research and Innovation Programme under the grant agreement number 952603.

Funding

This study is supported by Research Councils\u2019 UK Centre for Ageing and Vitality at Newcastle University [Grant Number L016354]. NO, LV, DP, AR, GAM, and DGJ are supported by the European Horizon 2020 Research and Innovation Programme under the grant agreement number 952603. The funding sources did not have a direct role in the design, collection, analysis, or interpretation of data, nor in the manuscript preparation, which is solely the remit of the author(s).

Funders	Funder number
European Horizon 2020
European Horizon 2020	952603
Research Councils UK Newcastle Centre for Ageing and Vitality	L016354

Keywords

Aged
Chronic Disease
Exercise Tolerance/physiology
Female
Heart Failure/diagnosis
Hemodynamics
Humans
Middle Aged
Prospective Studies
Quality of Life
Stroke Volume/physiology
Ventricular Function, Left/physiology

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10.1186/s12872-022-02829-wLicence: CC BY

PublishedFinal published version, 965 KBLicence: CC BY

Cite this

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title = "Haemodynamic determinants of quality of life in chronic heart failure",

abstract = "BACKGROUND: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure.METHODS: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire.RESULTS: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O 2 consumption (r = - 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = - 0.08, p = 0.60). CONCLUSION: Peak O 2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients. ",

keywords = "Aged, Chronic Disease, Exercise Tolerance/physiology, Female, Heart Failure/diagnosis, Hemodynamics, Humans, Middle Aged, Prospective Studies, Quality of Life, Stroke Volume/physiology, Ventricular Function, Left/physiology",

author = "Serlie Fatrin and Okwose, {Nduka C} and Kristian Bailey and Lazar Velicki and Dejana Popovic and Arsen Ristic and Seferovic, {Petar M} and MacGowan, {Guy A} and Jakovljevic, {Djordje G}",

note = "This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.",

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doi = "10.1186/s12872-022-02829-w",

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AU - Fatrin, Serlie

AU - Okwose, Nduka C

AU - Bailey, Kristian

AU - Velicki, Lazar

AU - Popovic, Dejana

AU - Ristic, Arsen

AU - Seferovic, Petar M

AU - MacGowan, Guy A

AU - Jakovljevic, Djordje G

N1 - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

PY - 2022/9/16

Y1 - 2022/9/16

N2 - BACKGROUND: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure.METHODS: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire.RESULTS: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O 2 consumption (r = - 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = - 0.08, p = 0.60). CONCLUSION: Peak O 2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.

AB - BACKGROUND: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure.METHODS: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire.RESULTS: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O 2 consumption (r = - 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = - 0.08, p = 0.60). CONCLUSION: Peak O 2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.

KW - Aged

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KW - Female

KW - Heart Failure/diagnosis

KW - Hemodynamics

KW - Humans

KW - Middle Aged

KW - Prospective Studies

KW - Quality of Life

KW - Stroke Volume/physiology

KW - Ventricular Function, Left/physiology

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U2 - 10.1186/s12872-022-02829-w

DO - 10.1186/s12872-022-02829-w

M3 - Article

C2 - 36114473

SN - 1471-2261

VL - 22

JO - BMC Cardiovascular Disorders

JF - BMC Cardiovascular Disorders

IS - 1

M1 - 412

ER -

Haemodynamic determinants of quality of life in chronic heart failure

Abstract

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