Haemodynamic determinants of quality of life in chronic heart failure

Serlie Fatrin, Nduka C Okwose, Kristian Bailey, Lazar Velicki, Dejana Popovic, Arsen Ristic, Petar M Seferovic, Guy A MacGowan, Djordje G Jakovljevic

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    BACKGROUND: Heart failure patients demonstrate reduced functional capacity, hemodynamic function, and quality of life (QOL) which are associated with high mortality and morbidity rate. The aim of the present study was to assess the relationship between functional capacity, hemodynamic response to exercise and QOL in chronic heart failure.

    METHODS: A single-centre prospective study recruited 42 chronic heart failure patients (11 females, mean age 60 ± 10 years) with reduced left ventricular ejection fraction (LVEF = 23 ± 7%). All participants completed a maximal graded cardiopulmonary exercise test with non-invasive hemodynamic (bioreactance) monitoring. QOL was assessed using Minnesota Living with Heart Failure Questionnaire.

    RESULTS: The average value of QOL score was 40 ± 23. There was a significant negative relationship between the QOL and peak O 2 consumption (r = - 0.50, p ≤ 0.01). No significant relationship between the QOL and selected exercise hemodynamic measures was found, including peak exercise cardiac power output (r = 0.15, p = 0.34), cardiac output (r = 0.22, p = 0.15), and mean arterial blood pressure (r = - 0.08, p = 0.60).

    CONCLUSION: Peak O 2 consumption, but not hemodynamic response to exercise, is a significant determinant of QOL in chronic heart failure patients.

    Original languageEnglish
    Article number412
    Number of pages6
    JournalBMC Cardiovascular Disorders
    Issue number1
    Early online date16 Sept 2022
    Publication statusE-pub ahead of print - 16 Sept 2022

    Bibliographical note

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    This study is supported by Research Councils’ UK Centre for Ageing and Vitality at Newcastle University [Grant Number L016354]. NO, LV, DP, AR, GAM, and DGJ are supported by the European Horizon 2020 Research and Innovation Programme under the grant agreement number 952603.


    • Aged
    • Chronic Disease
    • Exercise Tolerance/physiology
    • Female
    • Heart Failure/diagnosis
    • Hemodynamics
    • Humans
    • Middle Aged
    • Prospective Studies
    • Quality of Life
    • Stroke Volume/physiology
    • Ventricular Function, Left/physiology


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