GSTP1 and GSTA1 polymorphisms interact with cruciferous vegetable intake in colorectal adenoma risk

Mariken J. Tijhuis, Petra A. Wark, Jac M M J G Aarts, Marleen H P W Visker, Fokko M. Nagengast, Frans J. Kok, Ellen Kampman

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    36 Citations (Scopus)

    Abstract

    The possible interplay between cruciferous vegetable consumption, functional genetic variations in glutathione S-transferases (GST) M1, T1, P1, and A1, and colorectal adenomas, was investigated in a Dutch case-control study. The GSTM1 and GSTT1 deletion polymorphisms, and the single nucleotide polymorphisms in GSTP1 (A313G) and in GSTA1 (C-69T) were assessed among 746 cases who developed colorectal adenomas and 698 endoscopy-based controls without any type of colorectal polyps. High and low cruciferous vegetable consumption was defined based on a median split in the control group. High consumption was slightly positively associated with colorectal adenomas [odds ratio (OR) 1.15; 95% confidence interval, 0.92-1.44]. For GSTP1, a positive association with higher cruciferous vegetable intake was only apparent in individuals with the low-activity GSTP1 genotype (GG genotype, OR 1.94; 95% confidence interval, 1.02-3.69). This interaction was more pronounced in men, with higher age and with higher meat intake. The GSTA1 polymorphism may have a modifying role as well: the OR for higher intake compared with lower intake was 1.57 (0.93-2.65) for individuals homozygous for the low expression variant (TT genotype). This seemed to be stronger with younger age and higher red meat intake. Cruciferous vegetable consumption and the combined GSTA1 and GSTPl genotypes showed a statistically significant interaction (P = 0.034). The GSTM1 and GSTT1 genotypes did not seem to modify the association between cruciferous vegetable intake and colorectal adenomas. In conclusion, GSTP1 and GSTA1 genotypes might modulate the association between cruciferous vegetable intake and colorectal adenomas.

    Original languageEnglish
    Pages (from-to)2943-2951
    Number of pages9
    JournalCancer Epidemiology Biomarkers and Prevention
    Volume14
    Issue number12
    DOIs
    Publication statusPublished - 19 Dec 2005

    ASJC Scopus subject areas

    • Epidemiology
    • Oncology

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    Tijhuis, M. J., Wark, P. A., Aarts, J. M. M. J. G., Visker, M. H. P. W., Nagengast, F. M., Kok, F. J., & Kampman, E. (2005). GSTP1 and GSTA1 polymorphisms interact with cruciferous vegetable intake in colorectal adenoma risk. Cancer Epidemiology Biomarkers and Prevention, 14(12), 2943-2951. https://doi.org/10.1158/1055-9965.EPI-05-0591