Growth hormone/STAT5 signaling in proopiomelanocortin neurons regulates glucoprivic hyperphagia

Paula G F Quaresma, Pryscila D S Teixeira, Isadora C Furigo, Frederick Wasinski, Gisele C Couto, Renata Frazão, Edward O List, John J Kopchick, Jose Donato

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Several hypothalamic neuronal populations are directly responsive to growth hormone (GH) and central GH action regulates glucose and energy homeostasis. However, the potential role of GH signaling in proopiomelanocortin (POMC) neurons has not been studied yet. Thus, we investigated whether POMC neurons are responsive to GH and if ablation of GH receptor (GHR) or STAT5 in POMC cells leads to metabolic imbalances. Approximately 60% of POMC neurons of the arcuate nucleus exhibited STAT5 phosphorylation after intracerebroventricular GH injection. Ablation of GHR or STAT5 in POMC cells did not affect energy or glucose homeostasis. However, glucoprivic hyperphagia was blunted in male and female GHR knockout mice, and in male POMC-specific STAT5 knockout mice. Additionally, the absence of GHR in POMC neurons decreased glycemia during prolonged food restriction in male mice. Thus, GH action in POMC neurons regulates glucoprivic hyperphagia as well as blood glucose levels during prolonged food restriction.

Original languageEnglish
Article number110574
Number of pages14
JournalMolecular and Cellular Endocrinology
Volume498
Early online date5 Sept 2019
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Bibliographical note

Copyright © 2019 Elsevier B.V. All rights reserved.

Keywords

  • Energy metabolism
  • Food restriction
  • Glucose metabolism
  • Hypoglycemia
  • Melanocortin system
  • POMC

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