gp120‐induced programmed cell death in recently activated T cells without subsequent ligation of the T cell receptor

Serene Foster, Peter Beverley, Richard Aspinall

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In most individuals, HIV infection is characterized by a progressive decline in the number of peripheral blood CD4+ T lymphocytes, and while the number of CD4+ cells is within the normal range, defects in immune function are detectable. To date neither the decline in function nor the decline in cell number have been satisfactorily explained. Here we describe a mechanism which may contribute to the immunodeficiency and decline in CD4+ cell numbers in HIV‐infected individuals. We show that recently activated T cells are susceptible to apoptosis when exposed to HIV gp120 in the presence of anti‐gp120 antibody.

Original languageEnglish
Pages (from-to)1778-1782
Number of pages5
JournalEuropean Journal of Immunology
Volume25
Issue number6
DOIs
Publication statusPublished - Jun 1995
Externally publishedYes

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Keywords

  • Activated T cells
  • gp120
  • Programmed cell death

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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