Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: Its occurrence and role

Mark Wheatley, Stuart R. Hawtin

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Many hormones that are central to normal reproductive functioning mediate their physiological effects by activating a receptor which belongs to the large family of G-protein-coupled receptors (GPCR). Members of this family of receptor proteins are usually glycosylated on extracellular domains. In recent years the role of this glycosylation in cell surface expression/protein folding, ligand recognition and receptor-effector coupling has been investigated. This review summarises current knowledge of the role of glycosylation in the functioning of the receptors for gonadotrophin-releasing hormone (GnRH), luteinizing hormone/human chorionic gonadotrophin (LH/HCG), follicle stimulating hormone (FSH), oxytocin (OT) and vasopressin (AVP).

Original languageEnglish
Pages (from-to)356-364
Number of pages9
JournalHuman Reproduction Update
Volume5
Issue number4
DOIs
Publication statusPublished - Jul 1999
Externally publishedYes

Bibliographical note

Free access

Keywords

  • Glycohormone receptors
  • Glycosylation
  • Gonadotrophin-releasing hormone receptor
  • Oxytocin receptor
  • Vasopressin receptor

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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