Genetic risk factors for musculoskeletal soft tissue injuries

Malcolm Collins, Stuart M Raleigh

Research output: Chapter in Book/Report/Conference proceedingChapter

82 Citations (Scopus)

Abstract

Acute and overuse musculoskeletal soft tissues injuries are common as a result of participating in specific physical or workplace activities. Multiple risk factors, including genetic factors, are implicated in the aetiology of these injuries. Common musculoskeletal soft tissue injuries for which a genetic contribution has been proposed include the Achilles tendon in the heel, the rotator cuff tendons in the shoulder and the cruciate ligaments in the knee. Recent developments in the identification of genetic risk factors for tendon and ligament injuries will be reviewed. Sequence variants within genes that encode for several tendon and/or ligament extracellular matrix proteins have been shown to be associated with specific musculoskeletal soft tissues injuries. Variants within the TNC, COL5A1 and MMP3 genes co-segregate with chronic Achilles tendinopathy. The variant within the TNC gene also appears to co-segregate with Achilles tendon ruptures, while sequence variants within the COL1A1 and COL5A1 genes have been shown to be associated with cruciate ligament ruptures and/or shoulder dislocations. Whether these variants are directly involved in the development of these musculoskeletal soft tissue abnormalities or in strong linkage disequilibrium with actual disease-causing loci remains to be established. We proposed that genetic risk factors will in the future be included in multifactorial models developed to understand the molecular mechanisms that cause musculoskeletal soft tissue injuries or related pathology. Clinicians could eventually use these models to develop personalised training programmes to reduce the risk of injury as well as to develop treatment and rehabilitation regimens for the injured individual.

Original languageEnglish
Title of host publicationGenetics and Sports
EditorsM. Collins
Pages136-49
Number of pages14
Volume54
ISBN (Electronic)978-3-8055-9028-0
DOIs
Publication statusPublished - 2009

Publication series

NameMedicine and sport science
ISSN (Print)0254-5020

Keywords

  • ADAM Proteins
  • Chromosomes, Human, Pair 9
  • Collagen
  • Collagen Type I
  • Genetic Predisposition to Disease
  • Humans
  • Ligaments
  • Matrix Metalloproteinases
  • Mutation
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Soft Tissue Injuries
  • Tenascin
  • Tendon Injuries
  • Tendons
  • Journal Article

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  • Cite this

    Collins, M., & Raleigh, S. M. (2009). Genetic risk factors for musculoskeletal soft tissue injuries. In M. Collins (Ed.), Genetics and Sports (Vol. 54, pp. 136-49). (Medicine and sport science). https://doi.org/10.1159/000235701