TY - JOUR
T1 - Genetic and Epigenetic Factors That Predispose to Musculoskeletal Disorders
AU - Raleigh, Stuart M.
N1 - This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
PY - 2024/9/11
Y1 - 2024/9/11
N2 - Musculoskeletal soft tissue disorders (MSTDs) are a heterogenous group of maladies that can affect the muscles, bones, nerves, joints, ligaments, tendons, cartilage, and adjoining structures and seriously impact on the quality of life in those affected. In some cases, immune system dysregulation is involved (for example, in rheumatoid arthritis), and in other cases, such as sports-related Achilles tendinopathy, there does not seem to be an underlying immune system pathology. The prevalence of these conditions varies widely, depending on the type of disorder and the location affected. For example, the lifetime prevalence of rotator cuff tendinopathy/shoulder pain is around 67%, whereas scoliosis affects approximately 8% of the population under 25 years of age, rising to 68% in those over 60. In this Special Issue, we received five detailed studies that focused predominantly on the molecular genetics of MSTDs and one article that focused on epigenetic factors. We explore these publications in the following paragraphs.
AB - Musculoskeletal soft tissue disorders (MSTDs) are a heterogenous group of maladies that can affect the muscles, bones, nerves, joints, ligaments, tendons, cartilage, and adjoining structures and seriously impact on the quality of life in those affected. In some cases, immune system dysregulation is involved (for example, in rheumatoid arthritis), and in other cases, such as sports-related Achilles tendinopathy, there does not seem to be an underlying immune system pathology. The prevalence of these conditions varies widely, depending on the type of disorder and the location affected. For example, the lifetime prevalence of rotator cuff tendinopathy/shoulder pain is around 67%, whereas scoliosis affects approximately 8% of the population under 25 years of age, rising to 68% in those over 60. In this Special Issue, we received five detailed studies that focused predominantly on the molecular genetics of MSTDs and one article that focused on epigenetic factors. We explore these publications in the following paragraphs.
UR - https://www.scopus.com/pages/publications/85205115908
U2 - 10.3390/genes15091194
DO - 10.3390/genes15091194
M3 - Editorial
SN - 2073-4425
VL - 15
JO - Genes
JF - Genes
IS - 9
M1 - 1194
ER -