G-protein-coupled receptors: From structural insights to functional mechanisms

Bice Chini; Marco Parenti; David R. Poyner; Mark Wheatley

doi:10.1042/BST20120344

G-protein-coupled receptors: From structural insights to functional mechanisms

Bice Chini, Marco Parenti, David R. Poyner, Mark Wheatley

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The papers resulting from the recent Biochemical Society Focused Meeting 'G-Protein-Coupled Receptors: from Structural Insights to Functional Mechanisms' held in Prato in September 2012 are introduced in the present overview. A number of future goals for GPCR (G-protein-coupled receptor) research are considered, including the need to develop biophysical and computational methods to explore the full range of GPCR conformations and their dynamics, the need to develop methods to take this into account for drug discovery and the importance of relating observations on isolated receptors or receptors expressed in model systems to receptor function in vivo.

Original language	English
Pages (from-to)	135-136
Number of pages	2
Journal	Biochemical Society Transactions
Volume	41
Issue number	1
DOIs	https://doi.org/10.1042/BST20120344
Publication status	Published - 29 Jan 2013
Externally published	Yes

Keywords

β-arrestin
Crystal structure
G-protein-coupled receptor (GPCR)
Modelling
Pharmacology

ASJC Scopus subject areas

Biochemistry

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KW - β-arrestin

KW - Crystal structure

KW - G-protein-coupled receptor (GPCR)

KW - Modelling

KW - Pharmacology

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G-protein-coupled receptors: From structural insights to functional mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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