G-protein-coupled receptor phosphorylation and palmitoylation.

Andrew B. Tobin, Mark Wheatley

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


It is now clear that nearly all G-protein-coupled receptors (GPCRs) are phosphorylated and palmitolyated. The process of receptor phosphorylation has been extensively studied because it offers a regulatory mechanism that is both rapid and dynamic. However, it has recently become clear that palmitoyaltion of GPCRs at C-terminal cysteine residues may also offer dynamic receptor modification. A growing number of GPCRs have been demonstrated to undergo rapid agonist-mediated changes in their palmitoylation status with functional implications to receptor signaling. This chapter aims to outline the methods we have used to investigate agonist-mediated changes in GPCR phosphorylation and palmitoylation.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalMethods in molecular biology (Clifton, N.J.)
Publication statusPublished - 2004
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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