Fresh Fruit Consumption and Major Cardiovascular Disease in China

China Kadoorie Biobank (CKB) collaborative group

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

BACKGROUND: In Western populations, a higher level of fruit consumption has been associated with a lower risk of cardiovascular disease, but little is known about such associations in China, where the consumption level is low and rates of stroke are high.

METHODS: Between 2004 and 2008, we recruited 512,891 adults, 30 to 79 years of age, from 10 diverse localities in China. During 3.2 million person-years of follow-up, 5173 deaths from cardiovascular disease, 2551 incident major coronary events (fatal or nonfatal), 14,579 ischemic strokes, and 3523 intracerebral hemorrhages were recorded among the 451,665 participants who did not have a history of cardiovascular disease or antihypertensive treatments at baseline. Cox regression yielded adjusted hazard ratios relating fresh fruit consumption to disease rates.

RESULTS: Overall, 18.0% of participants reported consuming fresh fruit daily. As compared with participants who never or rarely consumed fresh fruit (the "nonconsumption" category), those who ate fresh fruit daily had lower systolic blood pressure (by 4.0 mm Hg) and blood glucose levels (by 0.5 mmol per liter [9.0 mg per deciliter]) (P<0.001 for trend for both comparisons). The adjusted hazard ratios for daily consumption versus nonconsumption were 0.60 (95% confidence interval [CI], 0.54 to 0.67) for cardiovascular death, and 0.66 (95% CI, 0.58 to 0.75), 0.75 (95% CI, 0.72 to 0.79), and 0.64 (95% CI, 0.56 to 0.74), respectively, for incident major coronary events, ischemic stroke, and hemorrhagic stroke. There was a strong log-linear dose-response relationship between the incidence of each outcome and the amount of fresh fruit consumed. These associations were similar across the 10 study regions and in subgroups of participants defined by baseline characteristics.

CONCLUSIONS: Among Chinese adults, a higher level of fruit consumption was associated with lower blood pressure and blood glucose levels and, largely independent of these and other dietary and nondietary factors, with significantly lower risks of major cardiovascular diseases. (Funded by the Wellcome Trust and others.).

Original languageEnglish
Pages (from-to)1332-1343
Number of pages12
JournalHealth
Volume374
Issue number14
DOIs
Publication statusPublished - 7 Apr 2016
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Blood Glucose/analysis
  • Blood Pressure
  • Body Mass Index
  • Cardiovascular Diseases/epidemiology
  • China/epidemiology
  • Diet
  • Diet Surveys
  • Female
  • Follow-Up Studies
  • Fruit
  • Humans
  • Hyperglycemia/epidemiology
  • Hypertension/epidemiology
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Risk Factors

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  • Cite this

    China Kadoorie Biobank (CKB) collaborative group (2016). Fresh Fruit Consumption and Major Cardiovascular Disease in China. Health, 374(14), 1332-1343. https://doi.org/10.1056/NEJMoa1501451