Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

R. Zamora-Ros; C. Sacerdote; F. Ricceri; E. Weiderpass; N. Roswall; G. Buckland; D. E. St-Jules; K. Overvad; C. Kyrø; G. Fagherazzi; M. Kvaskoff; G. Severi; J. Chang-Claude; R. Kaaks; U. Nöthlings; A. Trichopoulou; A. Naska; D. Trichopoulos; D. Palli; S. Grioni; A. Mattiello; R. Tumino; I. T. Gram; D. Engeset; J. M. Huerta; E. Molina-Montes; M. Argüelles; P. Amiano; E. Ardanaz; U. Ericson; B. Lindkvist; L. M. Nilsson; L. A. Kiemeney; M. Ros; H. B. Bueno-De-Mesquita; P. H M Peeters; K. T. Khaw; N. J. Wareham; V. Knaze; I. Romieu; A. Scalbert; P. Brennan; P. Wark; P. Vineis; E. Riboli; C. A. González

doi:10.1038/bjc.2014.459

Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

R. Zamora-Ros, C. Sacerdote, F. Ricceri, E. Weiderpass, N. Roswall, G. Buckland, D. E. St-Jules, K. Overvad, C. Kyrø, G. Fagherazzi, M. Kvaskoff, G. Severi, J. Chang-Claude, R. Kaaks, U. Nöthlings, A. Trichopoulou, A. Naska, D. Trichopoulos, D. Palli, S. GrioniA. Mattiello, R. Tumino, I. T. Gram, D. Engeset, J. M. Huerta, E. Molina-Montes, M. Argüelles, P. Amiano, E. Ardanaz, U. Ericson, B. Lindkvist, L. M. Nilsson, L. A. Kiemeney, M. Ros, H. B. Bueno-De-Mesquita, P. H M Peeters, K. T. Khaw, N. J. Wareham, V. Knaze, I. Romieu, A. Scalbert, P. Brennan, P. Wark, P. Vineis, E. Riboli, C. A. González

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Abstract

Background: There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Methods: A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.

Results: During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.

Conclusions: Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

Original language	English
Pages (from-to)	1870-1880
Number of pages	11
Journal	British Journal of Cancer
Volume	111
Issue number	9
Early online date	14 Aug 2014
DOIs	https://doi.org/10.1038/bjc.2014.459
Publication status	Published - 28 Oct 2014

Keywords

bladder cancer
dietary intake
EPIC
flavonoids
lignans

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Zamora-Ros, R., Sacerdote, C., Ricceri, F., Weiderpass, E., Roswall, N., Buckland, G., St-Jules, D. E., Overvad, K., Kyrø, C., Fagherazzi, G., Kvaskoff, M., Severi, G., Chang-Claude, J., Kaaks, R., Nöthlings, U., Trichopoulou, A., Naska, A., Trichopoulos, D., Palli, D., ... González, C. A. (2014). Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. British Journal of Cancer, 111(9), 1870-1880. https://doi.org/10.1038/bjc.2014.459

Zamora-Ros, R, Sacerdote, C, Ricceri, F, Weiderpass, E, Roswall, N, Buckland, G, St-Jules, DE, Overvad, K, Kyrø, C, Fagherazzi, G, Kvaskoff, M, Severi, G, Chang-Claude, J, Kaaks, R, Nöthlings, U, Trichopoulou, A, Naska, A, Trichopoulos, D, Palli, D, Grioni, S, Mattiello, A, Tumino, R, Gram, IT, Engeset, D, Huerta, JM, Molina-Montes, E, Argüelles, M, Amiano, P, Ardanaz, E, Ericson, U, Lindkvist, B, Nilsson, LM, Kiemeney, LA, Ros, M, Bueno-De-Mesquita, HB, Peeters, PHM, Khaw, KT, Wareham, NJ, Knaze, V, Romieu, I, Scalbert, A, Brennan, P, Wark, P, Vineis, P, Riboli, E & González, CA 2014, 'Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study', British Journal of Cancer, vol. 111, no. 9, pp. 1870-1880. https://doi.org/10.1038/bjc.2014.459

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title = "Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study",

abstract = "Background: There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods: A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results: During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions: Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.",

keywords = "bladder cancer, dietary intake, EPIC, flavonoids, lignans",

author = "R. Zamora-Ros and C. Sacerdote and F. Ricceri and E. Weiderpass and N. Roswall and G. Buckland and St-Jules, {D. E.} and K. Overvad and C. Kyr{\o} and G. Fagherazzi and M. Kvaskoff and G. Severi and J. Chang-Claude and R. Kaaks and U. N{\"o}thlings and A. Trichopoulou and A. Naska and D. Trichopoulos and D. Palli and S. Grioni and A. Mattiello and R. Tumino and Gram, {I. T.} and D. Engeset and Huerta, {J. M.} and E. Molina-Montes and M. Arg{\"u}elles and P. Amiano and E. Ardanaz and U. Ericson and B. Lindkvist and Nilsson, {L. M.} and Kiemeney, {L. A.} and M. Ros and Bueno-De-Mesquita, {H. B.} and Peeters, {P. H M} and Khaw, {K. T.} and Wareham, {N. J.} and V. Knaze and I. Romieu and A. Scalbert and P. Brennan and P. Wark and P. Vineis and E. Riboli and Gonz{\'a}lez, {C. A.}",

year = "2014",

month = oct,

day = "28",

doi = "10.1038/bjc.2014.459",

language = "English",

volume = "111",

pages = "1870--1880",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Cancer Research UK",

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TY - JOUR

T1 - Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

AU - Zamora-Ros, R.

AU - Sacerdote, C.

AU - Ricceri, F.

AU - Weiderpass, E.

AU - Roswall, N.

AU - Buckland, G.

AU - St-Jules, D. E.

AU - Overvad, K.

AU - Kyrø, C.

AU - Fagherazzi, G.

AU - Kvaskoff, M.

AU - Severi, G.

AU - Chang-Claude, J.

AU - Kaaks, R.

AU - Nöthlings, U.

AU - Trichopoulou, A.

AU - Naska, A.

AU - Trichopoulos, D.

AU - Palli, D.

AU - Grioni, S.

AU - Mattiello, A.

AU - Tumino, R.

AU - Gram, I. T.

AU - Engeset, D.

AU - Huerta, J. M.

AU - Molina-Montes, E.

AU - Argüelles, M.

AU - Amiano, P.

AU - Ardanaz, E.

AU - Ericson, U.

AU - Lindkvist, B.

AU - Nilsson, L. M.

AU - Kiemeney, L. A.

AU - Ros, M.

AU - Bueno-De-Mesquita, H. B.

AU - Peeters, P. H M

AU - Khaw, K. T.

AU - Wareham, N. J.

AU - Knaze, V.

AU - Romieu, I.

AU - Scalbert, A.

AU - Brennan, P.

AU - Wark, P.

AU - Vineis, P.

AU - Riboli, E.

AU - González, C. A.

PY - 2014/10/28

Y1 - 2014/10/28

N2 - Background: There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods: A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results: During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions: Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

AB - Background: There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods: A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results: During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions: Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

KW - bladder cancer

KW - dietary intake

KW - EPIC

KW - flavonoids

KW - lignans

U2 - 10.1038/bjc.2014.459

DO - 10.1038/bjc.2014.459

M3 - Article

C2 - 25121955

AN - SCOPUS:84908607376

SN - 0007-0920

VL - 111

SP - 1870

EP - 1880

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 9

ER -

Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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