Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Esther Molina-Montes; María José Sánchez; Raul Zamora-Ros; H. Bas Bueno-de-Mesquita; Petra A. Wark; Mireia Obon-Santacana; Tilman Kühn; Verena Katzke; Ruth C. Travis; Weimin Ye; Malin Sund; Alessio Naccarati; Amalia Mattiello; Vittorio Krogh; Caterina Martorana; Giovanna Masala; Pilar Amiano; José María Huerta; Aurelio Barricarte; José Ramón Quirós; Elisabete Weiderpass; Lene Angell Åsli; Guri Skeie; Ulrika Ericson; Emily Sonestedt; Petra H. Peeters; Isabelle Romieu; Augustin Scalbert; Kim Overvad; Matthias Clemens; Heiner Boeing; Antonia Trichopoulou; Eleni Peppa; Pavlos Vidalis; Kay Tee Khaw; Nick Wareham; Anja Olsen; Anne Tjønneland; Marie Christine Boutroun-Rualt; Françoise Clavel-Chapelon; Amanda J. Cross; Yunxia Lu; Elio Riboli; Eric J. Duell

doi:10.1002/ijc.30190

Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Esther Molina-Montes, María José Sánchez, Raul Zamora-Ros, H. Bas Bueno-de-Mesquita, Petra A. Wark, Mireia Obon-Santacana, Tilman Kühn, Verena Katzke, Ruth C. Travis, Weimin Ye, Malin Sund, Alessio Naccarati, Amalia Mattiello, Vittorio Krogh, Caterina Martorana, Giovanna Masala, Pilar Amiano, José María Huerta, Aurelio Barricarte, José Ramón QuirósElisabete Weiderpass, Lene Angell Åsli, Guri Skeie, Ulrika Ericson, Emily Sonestedt, Petra H. Peeters, Isabelle Romieu, Augustin Scalbert, Kim Overvad, Matthias Clemens, Heiner Boeing, Antonia Trichopoulou, Eleni Peppa, Pavlos Vidalis, Kay Tee Khaw, Nick Wareham, Anja Olsen, Anne Tjønneland, Marie Christine Boutroun-Rualt, Françoise Clavel-Chapelon, Amanda J. Cross, Yunxia Lu, Elio Riboli, Eric J. Duell

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Abstract

Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

Original language	English
Pages (from-to)	1480-1492
Number of pages	13
Journal	International Journal of Cancer
Volume	139
Issue number	7
Early online date	17 May 2016
DOIs	https://doi.org/10.1002/ijc.30190
Publication status	Published - 1 Oct 2016

Keywords

cohort
diet
flavonoids
lignans
pancreatic cancer

ASJC Scopus subject areas

General Medicine
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Molina-Montes, E., Sánchez, M. J., Zamora-Ros, R., Bueno-de-Mesquita, H. B., Wark, P. A., Obon-Santacana, M., Kühn, T., Katzke, V., Travis, R. C., Ye, W., Sund, M., Naccarati, A., Mattiello, A., Krogh, V., Martorana, C., Masala, G., Amiano, P., Huerta, J. M., Barricarte, A., ... Duell, E. J. (2016). Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort. International Journal of Cancer, 139(7), 1480-1492. https://doi.org/10.1002/ijc.30190

Molina-Montes, E, Sánchez, MJ, Zamora-Ros, R, Bueno-de-Mesquita, HB, Wark, PA, Obon-Santacana, M, Kühn, T, Katzke, V, Travis, RC, Ye, W, Sund, M, Naccarati, A, Mattiello, A, Krogh, V, Martorana, C, Masala, G, Amiano, P, Huerta, JM, Barricarte, A, Quirós, JR, Weiderpass, E, Angell Åsli, L, Skeie, G, Ericson, U, Sonestedt, E, Peeters, PH, Romieu, I, Scalbert, A, Overvad, K, Clemens, M, Boeing, H, Trichopoulou, A, Peppa, E, Vidalis, P, Khaw, KT, Wareham, N, Olsen, A, Tjønneland, A, Boutroun-Rualt, MC, Clavel-Chapelon, F, Cross, AJ, Lu, Y, Riboli, E & Duell, EJ 2016, 'Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort', International Journal of Cancer, vol. 139, no. 7, pp. 1480-1492. https://doi.org/10.1002/ijc.30190

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title = "Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort",

abstract = "Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.",

keywords = "cohort, diet, flavonoids, lignans, pancreatic cancer",

author = "Esther Molina-Montes and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Raul Zamora-Ros and Bueno-de-Mesquita, {H. Bas} and Wark, {Petra A.} and Mireia Obon-Santacana and Tilman K{\"u}hn and Verena Katzke and Travis, {Ruth C.} and Weimin Ye and Malin Sund and Alessio Naccarati and Amalia Mattiello and Vittorio Krogh and Caterina Martorana and Giovanna Masala and Pilar Amiano and Huerta, {Jos{\'e} Mar{\'i}a} and Aurelio Barricarte and Quir{\'o}s, {Jos{\'e} Ram{\'o}n} and Elisabete Weiderpass and {Angell {\AA}sli}, Lene and Guri Skeie and Ulrika Ericson and Emily Sonestedt and Peeters, {Petra H.} and Isabelle Romieu and Augustin Scalbert and Kim Overvad and Matthias Clemens and Heiner Boeing and Antonia Trichopoulou and Eleni Peppa and Pavlos Vidalis and Khaw, {Kay Tee} and Nick Wareham and Anja Olsen and Anne Tj{\o}nneland and Boutroun-Rualt, {Marie Christine} and Fran{\c c}oise Clavel-Chapelon and Cross, {Amanda J.} and Yunxia Lu and Elio Riboli and Duell, {Eric J.}",

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T1 - Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

AU - Molina-Montes, Esther

AU - Sánchez, María José

AU - Zamora-Ros, Raul

AU - Bueno-de-Mesquita, H. Bas

AU - Wark, Petra A.

AU - Obon-Santacana, Mireia

AU - Kühn, Tilman

AU - Katzke, Verena

AU - Travis, Ruth C.

AU - Ye, Weimin

AU - Sund, Malin

AU - Naccarati, Alessio

AU - Mattiello, Amalia

AU - Krogh, Vittorio

AU - Martorana, Caterina

AU - Masala, Giovanna

AU - Amiano, Pilar

AU - Huerta, José María

AU - Barricarte, Aurelio

AU - Quirós, José Ramón

AU - Weiderpass, Elisabete

AU - Angell Åsli, Lene

AU - Skeie, Guri

AU - Ericson, Ulrika

AU - Sonestedt, Emily

AU - Peeters, Petra H.

AU - Romieu, Isabelle

AU - Scalbert, Augustin

AU - Overvad, Kim

AU - Clemens, Matthias

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Peppa, Eleni

AU - Vidalis, Pavlos

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Boutroun-Rualt, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Cross, Amanda J.

AU - Lu, Yunxia

AU - Riboli, Elio

AU - Duell, Eric J.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

AB - Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

KW - cohort

KW - diet

KW - flavonoids

KW - lignans

KW - pancreatic cancer

U2 - 10.1002/ijc.30190

DO - 10.1002/ijc.30190

M3 - Article

C2 - 27184434

AN - SCOPUS:84978296091

SN - 0020-7136

VL - 139

SP - 1480

EP - 1492

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 7

ER -

Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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