Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Esther Molina-Montes, María José Sánchez, Raul Zamora-Ros, H. Bas Bueno-de-Mesquita, Petra A. Wark, Mireia Obon-Santacana, Tilman Kühn, Verena Katzke, Ruth C. Travis, Weimin Ye, Malin Sund, Alessio Naccarati, Amalia Mattiello, Vittorio Krogh, Caterina Martorana, Giovanna Masala, Pilar Amiano, José María Huerta, Aurelio Barricarte, José Ramón Quirós & 24 others Elisabete Weiderpass, Lene Angell Åsli, Guri Skeie, Ulrika Ericson, Emily Sonestedt, Petra H. Peeters, Isabelle Romieu, Augustin Scalbert, Kim Overvad, Matthias Clemens, Heiner Boeing, Antonia Trichopoulou, Eleni Peppa, Pavlos Vidalis, Kay Tee Khaw, Nick Wareham, Anja Olsen, Anne Tjønneland, Marie Christine Boutroun-Rualt, Françoise Clavel-Chapelon, Amanda J. Cross, Yunxia Lu, Elio Riboli, Eric J. Duell

    Research output: Contribution to journalArticle

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    Abstract

    Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

    Original languageEnglish
    Pages (from-to)1480-1492
    Number of pages13
    JournalInternational Journal of Cancer
    Volume139
    Issue number7
    Early online date17 May 2016
    DOIs
    Publication statusPublished - 1 Oct 2016

    Fingerprint

    Lignans
    Pancreatic Neoplasms
    Flavonoids
    Neoplasms
    Confidence Intervals
    Flavanones
    United States Department of Agriculture
    Aptitude
    Phenol
    Energy Intake
    Proportional Hazards Models
    Epidemiologic Studies
    Body Mass Index
    Smoking
    Alcohols
    Databases

    Keywords

    • cohort
    • diet
    • flavonoids
    • lignans
    • pancreatic cancer

    ASJC Scopus subject areas

    • Medicine(all)
    • Oncology
    • Cancer Research

    Cite this

    Molina-Montes, E., Sánchez, M. J., Zamora-Ros, R., Bueno-de-Mesquita, H. B., Wark, P. A., Obon-Santacana, M., ... Duell, E. J. (2016). Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort. International Journal of Cancer, 139(7), 1480-1492. https://doi.org/10.1002/ijc.30190

    Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort. / Molina-Montes, Esther; Sánchez, María José; Zamora-Ros, Raul; Bueno-de-Mesquita, H. Bas; Wark, Petra A.; Obon-Santacana, Mireia; Kühn, Tilman; Katzke, Verena; Travis, Ruth C.; Ye, Weimin; Sund, Malin; Naccarati, Alessio; Mattiello, Amalia; Krogh, Vittorio; Martorana, Caterina; Masala, Giovanna; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Quirós, José Ramón; Weiderpass, Elisabete; Angell Åsli, Lene; Skeie, Guri; Ericson, Ulrika; Sonestedt, Emily; Peeters, Petra H.; Romieu, Isabelle; Scalbert, Augustin; Overvad, Kim; Clemens, Matthias; Boeing, Heiner; Trichopoulou, Antonia; Peppa, Eleni; Vidalis, Pavlos; Khaw, Kay Tee; Wareham, Nick; Olsen, Anja; Tjønneland, Anne; Boutroun-Rualt, Marie Christine; Clavel-Chapelon, Françoise; Cross, Amanda J.; Lu, Yunxia; Riboli, Elio; Duell, Eric J.

    In: International Journal of Cancer, Vol. 139, No. 7, 01.10.2016, p. 1480-1492.

    Research output: Contribution to journalArticle

    Molina-Montes, E, Sánchez, MJ, Zamora-Ros, R, Bueno-de-Mesquita, HB, Wark, PA, Obon-Santacana, M, Kühn, T, Katzke, V, Travis, RC, Ye, W, Sund, M, Naccarati, A, Mattiello, A, Krogh, V, Martorana, C, Masala, G, Amiano, P, Huerta, JM, Barricarte, A, Quirós, JR, Weiderpass, E, Angell Åsli, L, Skeie, G, Ericson, U, Sonestedt, E, Peeters, PH, Romieu, I, Scalbert, A, Overvad, K, Clemens, M, Boeing, H, Trichopoulou, A, Peppa, E, Vidalis, P, Khaw, KT, Wareham, N, Olsen, A, Tjønneland, A, Boutroun-Rualt, MC, Clavel-Chapelon, F, Cross, AJ, Lu, Y, Riboli, E & Duell, EJ 2016, 'Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort' International Journal of Cancer, vol. 139, no. 7, pp. 1480-1492. https://doi.org/10.1002/ijc.30190
    Molina-Montes, Esther ; Sánchez, María José ; Zamora-Ros, Raul ; Bueno-de-Mesquita, H. Bas ; Wark, Petra A. ; Obon-Santacana, Mireia ; Kühn, Tilman ; Katzke, Verena ; Travis, Ruth C. ; Ye, Weimin ; Sund, Malin ; Naccarati, Alessio ; Mattiello, Amalia ; Krogh, Vittorio ; Martorana, Caterina ; Masala, Giovanna ; Amiano, Pilar ; Huerta, José María ; Barricarte, Aurelio ; Quirós, José Ramón ; Weiderpass, Elisabete ; Angell Åsli, Lene ; Skeie, Guri ; Ericson, Ulrika ; Sonestedt, Emily ; Peeters, Petra H. ; Romieu, Isabelle ; Scalbert, Augustin ; Overvad, Kim ; Clemens, Matthias ; Boeing, Heiner ; Trichopoulou, Antonia ; Peppa, Eleni ; Vidalis, Pavlos ; Khaw, Kay Tee ; Wareham, Nick ; Olsen, Anja ; Tjønneland, Anne ; Boutroun-Rualt, Marie Christine ; Clavel-Chapelon, Françoise ; Cross, Amanda J. ; Lu, Yunxia ; Riboli, Elio ; Duell, Eric J. / Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort. In: International Journal of Cancer. 2016 ; Vol. 139, No. 7. pp. 1480-1492.
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    abstract = "Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95{\%} confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95{\%} CI: 0.95–1.11 and 1.02; 95{\%} CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95{\%} CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.",
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    T1 - Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

    AU - Molina-Montes, Esther

    AU - Sánchez, María José

    AU - Zamora-Ros, Raul

    AU - Bueno-de-Mesquita, H. Bas

    AU - Wark, Petra A.

    AU - Obon-Santacana, Mireia

    AU - Kühn, Tilman

    AU - Katzke, Verena

    AU - Travis, Ruth C.

    AU - Ye, Weimin

    AU - Sund, Malin

    AU - Naccarati, Alessio

    AU - Mattiello, Amalia

    AU - Krogh, Vittorio

    AU - Martorana, Caterina

    AU - Masala, Giovanna

    AU - Amiano, Pilar

    AU - Huerta, José María

    AU - Barricarte, Aurelio

    AU - Quirós, José Ramón

    AU - Weiderpass, Elisabete

    AU - Angell Åsli, Lene

    AU - Skeie, Guri

    AU - Ericson, Ulrika

    AU - Sonestedt, Emily

    AU - Peeters, Petra H.

    AU - Romieu, Isabelle

    AU - Scalbert, Augustin

    AU - Overvad, Kim

    AU - Clemens, Matthias

    AU - Boeing, Heiner

    AU - Trichopoulou, Antonia

    AU - Peppa, Eleni

    AU - Vidalis, Pavlos

    AU - Khaw, Kay Tee

    AU - Wareham, Nick

    AU - Olsen, Anja

    AU - Tjønneland, Anne

    AU - Boutroun-Rualt, Marie Christine

    AU - Clavel-Chapelon, Françoise

    AU - Cross, Amanda J.

    AU - Lu, Yunxia

    AU - Riboli, Elio

    AU - Duell, Eric J.

    PY - 2016/10/1

    Y1 - 2016/10/1

    N2 - Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

    AB - Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

    KW - cohort

    KW - diet

    KW - flavonoids

    KW - lignans

    KW - pancreatic cancer

    U2 - 10.1002/ijc.30190

    DO - 10.1002/ijc.30190

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