Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1999-2010 |
| Number of pages | 12 |
| Journal | British Journal of Nutrition |
| Volume | 116 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 28 Dec 2016 |
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Keywords
- Citrus flavanones
- Endothelial function
- High-fat meals
- Nitric oxide
- Postprandial state
Cite this
Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study. / Rendeiro, Catarina; Dong, Honglin; Saunders, Caroline; Harkness, Laura; Blaze, Melvin; Hou, Yanpeng; Belanger, Ronald; Corona, Giulia; Lovegrove, Julie; Spencer, Jeremy.
In: British Journal of Nutrition, Vol. 116, No. 12, 28.12.2016, p. 1999-2010.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study
AU - Rendeiro, Catarina
AU - Dong, Honglin
AU - Saunders, Caroline
AU - Harkness, Laura
AU - Blaze, Melvin
AU - Hou, Yanpeng
AU - Belanger, Ronald
AU - Corona, Giulia
AU - Lovegrove, Julie
AU - Spencer, Jeremy
PY - 2016/12/28
Y1 - 2016/12/28
N2 - Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0–7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30–65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P <0·05), but no dose– response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.
AB - Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0–7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30–65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P <0·05), but no dose– response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.
KW - Citrus flavanones
KW - Endothelial function
KW - High-fat meals
KW - Nitric oxide
KW - Postprandial state
U2 - 10.1017/S0007114516004219
DO - 10.1017/S0007114516004219
M3 - Article
VL - 116
SP - 1999
EP - 2010
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 12
ER -