Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study

Catarina Rendeiro, Honglin Dong, Caroline Saunders, Laura Harkness, Melvin Blaze, Yanpeng Hou, Ronald Belanger, Giulia Corona, Julie Lovegrove, Jeremy Spencer

Research output: Contribution to journalArticle

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Abstract

Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0–7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30–65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P <0·05), but no dose– response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.
Original languageEnglish
Pages (from-to)1999-2010
Number of pages12
JournalBritish Journal of Nutrition
Volume116
Issue number12
DOIs
Publication statusPublished - 28 Dec 2016

Fingerprint

Citrus
Beverages
Cross-Over Studies
Flavanones
Dilatation
Blood Vessels
Meals
Nitric Oxide
Food and Beverages
Brachial Artery
Glucuronides
Nitrites
Flavonoids
Sulfates
Fats
flavanone
naringenin
hesperetin

Keywords

  • Citrus flavanones
  • Endothelial function
  • High-fat meals
  • Nitric oxide
  • Postprandial state

Cite this

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study. / Rendeiro, Catarina; Dong, Honglin; Saunders, Caroline; Harkness, Laura; Blaze, Melvin; Hou, Yanpeng; Belanger, Ronald; Corona, Giulia; Lovegrove, Julie; Spencer, Jeremy.

In: British Journal of Nutrition, Vol. 116, No. 12, 28.12.2016, p. 1999-2010.

Research output: Contribution to journalArticle

Rendeiro, Catarina ; Dong, Honglin ; Saunders, Caroline ; Harkness, Laura ; Blaze, Melvin ; Hou, Yanpeng ; Belanger, Ronald ; Corona, Giulia ; Lovegrove, Julie ; Spencer, Jeremy. / Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study. In: British Journal of Nutrition. 2016 ; Vol. 116, No. 12. pp. 1999-2010.
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AU - Dong, Honglin

AU - Saunders, Caroline

AU - Harkness, Laura

AU - Blaze, Melvin

AU - Hou, Yanpeng

AU - Belanger, Ronald

AU - Corona, Giulia

AU - Lovegrove, Julie

AU - Spencer, Jeremy

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AB - Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0–7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30–65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery at 0, 2, 5 and 7 h. Plasma levels of naringenin/hesperetin metabolites (sulphates and glucuronides) and nitric oxide species were also measured. All flavanone interventions were effective at attenuating transient impairments in FMD induced by the double meal (7 h post intake; P <0·05), but no dose– response effects were observed. The effects on FMD coincided with the peak of naringenin/hesperetin metabolites in circulation (7 h) and sustained levels of plasma nitrite. In summary, citrus flavanones are effective at counteracting the negative impact of a sequential double meal on human vascular function, potentially through the actions of flavanone metabolites on nitric oxide.

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KW - Nitric oxide

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