TY - JOUR
T1 - Female infertility caused by organophosphates
T2 - an insight into the latest biochemical and histomorphological findings
AU - Samare-Najaf, Mohammad
AU - Samareh, Ali
AU - Namavar Jahromi, Bahia
AU - Jamali, Navid
AU - Vakili, Sina
AU - Mohsenizadeh, Majid
AU - Clark, Cain C. T.
AU - Abbasi, Ali
AU - Khajehyar, Nastaran
PY - 2023/1/2
Y1 - 2023/1/2
N2 - The etiology of female infertility includes a variety of causes, all of which could be induced by environmental pollutants. Organophosphates (OPs) are major constituents of pollutants that cause infertility in aquatic and terrestrial organisms. However, no study has comprehensively reviewed the female fertility-related consequences of exposure to OPs. In this study, the reviewed studies revealed that OPs exposure could elicit detrimental alterations in organ histomorphology, sex hormone levels, and related signaling pathways. Furthermore, preconceptional exposure was associated with poor pregnancy outcomes, where prenatal exposure negatively impacted newborn health. Therefore, it is necessary to restrict the current widespread application of OPs or to alter their chemical structure so not to negatively impact female fertility.
AB - The etiology of female infertility includes a variety of causes, all of which could be induced by environmental pollutants. Organophosphates (OPs) are major constituents of pollutants that cause infertility in aquatic and terrestrial organisms. However, no study has comprehensively reviewed the female fertility-related consequences of exposure to OPs. In this study, the reviewed studies revealed that OPs exposure could elicit detrimental alterations in organ histomorphology, sex hormone levels, and related signaling pathways. Furthermore, preconceptional exposure was associated with poor pregnancy outcomes, where prenatal exposure negatively impacted newborn health. Therefore, it is necessary to restrict the current widespread application of OPs or to alter their chemical structure so not to negatively impact female fertility.
KW - Female infertility
KW - environmental pollutants
KW - organophosphates
KW - reproduction
KW - toxicity
UR - http://www.scopus.com/inward/record.url?scp=85138238911&partnerID=8YFLogxK
U2 - 10.1080/15569543.2022.2120897
DO - 10.1080/15569543.2022.2120897
M3 - Review article
SN - 1556-9543
VL - 42
SP - 419
EP - 446
JO - Toxin Reviews
JF - Toxin Reviews
IS - 1
ER -