Female infertility caused by organophosphates: an insight into the latest biochemical and histomorphological findings

Mohammad Samare-Najaf, Ali Samareh, Bahia Namavar Jahromi, Navid Jamali, Sina Vakili, Majid Mohsenizadeh, Cain C. T. Clark, Ali Abbasi, Nastaran Khajehyar

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)

    Abstract

    The etiology of female infertility includes a variety of causes, all of which could be induced by environmental pollutants. Organophosphates (OPs) are major constituents of pollutants that cause infertility in aquatic and terrestrial organisms. However, no study has comprehensively reviewed the female fertility-related consequences of exposure to OPs. In this study, the reviewed studies revealed that OPs exposure could elicit detrimental alterations in organ histomorphology, sex hormone levels, and related signaling pathways. Furthermore, preconceptional exposure was associated with poor pregnancy outcomes, where prenatal exposure negatively impacted newborn health. Therefore, it is necessary to restrict the current widespread application of OPs or to alter their chemical structure so not to negatively impact female fertility.

    Original languageEnglish
    Pages (from-to)419-446
    Number of pages28
    JournalToxin Reviews
    Volume42
    Issue number1
    Early online date9 Sept 2022
    DOIs
    Publication statusPublished - 2 Jan 2023

    Keywords

    • Female infertility
    • environmental pollutants
    • organophosphates
    • reproduction
    • toxicity

    ASJC Scopus subject areas

    • Toxicology

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