Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European prospective investigation into cancer and nutrition

Christina C. Dahm, Anders Gorst-Rasmussen, Francesca L. Crowe, Nina Roswall, Anne Tjnøneland, Dagmar Drogan, Heiner Boeing, Birgit Teucher, Rudolf Kaaks, George Adarakis, Dimosthenes Zylis, Antonia Trichopoulou, Veronika Fedirko, Veronique Chajes, Mazda Jenab, Domenico Palli, Valeria Pala, Rosario Tumino, Fulvio Ricceri, Henk Van KranenH. Bas Bueno-de-Mesquita, Jose R. Quiroś, María Jośe Śanchez, Leila Lujań-Barroso, Nerea Larranãga, María Dolores Chirlaque, Eva Ardanaz, Mattias Johansson, Pär Stattin, Kay Tee Khaw, Nick Wareham, Petra A. Wark, Teresa Norat, Elio Riboli, Tim J. Key, Kim Overvad

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    Background: Fatty acids in blood may be related to the risk of prostate cancer, but epidemiologic evidence is inconsistent. Blood fatty acids are correlated through shared food sources and common endogenous desaturation and elongation pathways. Studies of individual fatty acids cannot take this into account, but pattern analysis can. Treelet transform (TT) is a novel method that uses data correlation structures to derive sparse factors that explain variation. 

    Objective: The objective was to gain further insight in the association between plasma fatty acids and risk of prostate cancer by applying TT to take data correlations into account. 

    Design: We reanalyzed previously published data from a case-control study of prostate cancer nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. TT was used to derive factors explaining the variation in 26 plasma phospholipid fatty acids of 962 incident prostate cancer cases matched to 1061 controls. Multiple imputation was used to deal with missing data in covariates. ORs of prostate cancer according to factor scores were determined by using multivariable conditional logistic regression. 

    Results: Four simple factors explained 38% of the variation in plasma fatty acids. A high score on a factor reflecting a long-chain n - 3 PUFA pattern was associated with greater risk of prostate cancer (OR for highest compared with lowest quintile: 1.36; 95% CI: 0.99, 1.86; P-trend = 0.041). 

    Conclusion: Pattern analyses using TT groupings of correlated fatty acids indicate that intake or metabolism of long-chain n - 3 PUFAs may be relevant to prostate cancer etiology.

    Original languageEnglish
    Pages (from-to)1354-1361
    Number of pages8
    JournalAmerican Journal of Clinical Nutrition
    Volume96
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 2012

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

    Fingerprint Dive into the research topics of 'Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European prospective investigation into cancer and nutrition'. Together they form a unique fingerprint.

  • Cite this