Abstract
We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%±6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 227-234 |
| Number of pages | 8 |
| Journal | Journal of Hepatology |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 |
| Externally published | Yes |
Funding
This work was kindly supported by a grant from the Cancer Research Campaign. We would like to thank Colin Cooper for the gift of the c-met 1.1 kb cDNA, and Prof Morag Park for the gift of the 0.8 and 1.3 kb cDNA probes.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Hepatoma
- Human growth factor
- Scatter factor
- Tyrosine kinase receptor
ASJC Scopus subject areas
- Hepatology
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