Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

Clare Selden, Sebastien Farnaud, Shi Fa Ding, Nagy Habib, Christopher Foster, Humphrey J.F. Hodgson

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%±6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer.

Original languageEnglish
Pages (from-to)227-234
Number of pages8
JournalJournal of Hepatology
Volume21
Issue number2
DOIs
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • Hepatoma
  • Human growth factor
  • Scatter factor
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Hepatology

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