Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

Clare Selden; Sebastien Farnaud; Shi Fa Ding; Nagy Habib; Christopher Foster; Humphrey J.F. Hodgson

doi:10.1016/S0168-8278(05)80400-3

Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

Clare Selden, Sebastien Farnaud, Shi Fa Ding, Nagy Habib, Christopher Foster, Humphrey J.F. Hodgson

Royal Postgraduate Medical School

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%±6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer.

Original language	English
Pages (from-to)	227-234
Number of pages	8
Journal	Journal of Hepatology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/S0168-8278(05)80400-3
Publication status	Published - 1994
Externally published	Yes

Keywords

Hepatoma
Human growth factor
Scatter factor
Tyrosine kinase receptor

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0168-8278(05)80400-3

Cite this

@article{0ca0a63a73a24e95b850ebf6fcb1122e,

title = "Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours",

abstract = "We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%±6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer.",

keywords = "Hepatoma, Human growth factor, Scatter factor, Tyrosine kinase receptor",

author = "Clare Selden and Sebastien Farnaud and Ding, {Shi Fa} and Nagy Habib and Christopher Foster and Hodgson, {Humphrey J.F.}",

year = "1994",

doi = "10.1016/S0168-8278(05)80400-3",

language = "English",

volume = "21",

pages = "227--234",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

AU - Selden, Clare

AU - Farnaud, Sebastien

AU - Ding, Shi Fa

AU - Habib, Nagy

AU - Foster, Christopher

AU - Hodgson, Humphrey J.F.

PY - 1994

Y1 - 1994

N2 - We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%±6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer.

AB - We have quantified mRNA for the hepatocyte growth factor and its putative receptor the c-met proto-oncogene protein product, in a series of human primary and secondary liver tumours and adjacent non-neoplastic liver. In all hepatocellular cancers, hepatocyte growth factor 6 kb mRNA expression was less (mean 23.93%±6.33% S.E.M. n=7) in the tumours than in the adjacent normal liver. Both relative over- and under-expression of c-met transcripts were found in tumour tissue compared to non-neoplastic liver. Thus hepatocellular cancer tissue does not over-express mRNA for hepatocyte growth factor, though this growth factor might play a role in hyperproliferative states leading to liver cancer.

KW - Hepatoma

KW - Human growth factor

KW - Scatter factor

KW - Tyrosine kinase receptor

UR - http://www.scopus.com/inward/record.url?scp=0028071919&partnerID=8YFLogxK

U2 - 10.1016/S0168-8278(05)80400-3

DO - 10.1016/S0168-8278(05)80400-3

M3 - Article

C2 - 7989714

AN - SCOPUS:0028071919

SN - 0168-8278

VL - 21

SP - 227

EP - 234

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 2

ER -

Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this