Exercise modalities and endothelial function: a systematic review and dose-response meta-analysis of randomized controlled trials.

AW Ashor, J Lara, M Siervo, C Celis-Morales, C Oggioni, DG Jakovljevic, JC Mathers

    Research output: Contribution to journalArticlepeer-review

    108 Citations (Scopus)

    Abstract

    Background
    Regular exercise is associated with enhanced nitric oxide (NO) bioavailability. Flow-mediated dilation (FMD) is used widely to assess endothelial function (EF) and NO release.

    Objectives
    The aims of this systematic review and meta-analysis were to (i) investigate the effect of exercise modalities (aerobic, resistance or combined) on FMD; and (ii) determine which exercise and participant characteristics are most effective in improving FMD.

    Methods
    We searched the MEDLINE, Embase, Cochrane Library, and Scopus databases for studies that met the following criteria: (i) randomized controlled trials of exercise with comparative non-exercise, usual care or sedentary groups; (ii) duration of exercise intervention ≥4 weeks; (iii) age ≥18 years; and (iv) EF measured by FMD before and after the intervention. Weighted mean differences (WMDs) with 95 % confidence interval were entered into a random effect model to estimate the pooled effect of the exercise interventions.

    Results
    All exercise modalities enhanced EF significantly: aerobic (WMD 2.79, 95 % CI 2.12–3.45, p = 0.0001), resistance (WMD 2.52, 95 % CI 1.11–3.93, p = 0.0001) and combined (WMD 2.07, 95 % CI 0.70–3.44, p = 0.003). A dose–response relationship was observed between aerobic exercise intensity and improvement in EF. A 2 metabolic equivalents (MET) increase in absolute exercise intensity or a 10 % increase in relative exercise intensity resulted in a 1 % unit improvement in FMD. There was a positive relationship between frequency of resistance exercise sessions and improvement in EF (β 1.14, CI 0.16–2.12, p = 0.027).

    Conclusions
    All exercise modalities improve EF significantly and there was a significant, positive relationship between aerobic exercise intensity and EF. Greater frequency, rather than intensity, of resistance exercise training enhanced EF.
    Original languageEnglish
    Pages (from-to)279–296
    Number of pages18
    JournalSports Medicine
    Volume45
    DOIs
    Publication statusPublished - Feb 2015

    Keywords

    • Endothelial Function
    • Exercise Intensity
    • Resistance Exercise
    • Aerobic Exercise
    • Exercise Intervention

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