Exercise Induces Peripheral Muscle But Not Cardiac Adaptations After Stroke: A Randomized Controlled Pilot Trial

SA Moore, DG Jakovljevic, GA Ford, L Rochester, MI Trenell

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8 Citations (Scopus)
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Objective: To explore the physiological factors affecting exercise-induced changes in peak oxygen consumption and function poststroke. Design: Single-center, single-blind, randomized controlled pilot trial. Setting: Community stroke services. Participants: Adults (NZ40; age>50y; independent with/without stick) with stroke (diagnosed >6mo previously) were recruited from 117 eligible participants. Twenty participants were randomized to the intervention group and 20 to the control group. No dropouts or adverse events were reported. Interventions: Intervention group: 19-week (3times/wk) progressive mixed (aerobic/strength/balance/flexibility) community group exercise program. Control group: Matched duration home stretching program. Main Outcome Measures: (1) Pre- and postintervention: maximal cardiopulmonary exercise testing with noninvasive (bioreactance) cardiac output measurements; and (2) functional outcome measures: 6-minute walk test; timed Up and Go test, and Berg Balance Scale. Results: Exercise improved peak oxygen consumption (185 to 215mL/(kg,min); P<.01) and peak arterial-venous oxygen difference (9.22.7 to 11.42.9mL of O2/100mL of blood; P<.01), but did not alter cardiac output (17.24 to 17.74.2L/min; PZ.44) or cardiac power output (4.81.3 to 5.01.35W; PZ.45). A significant relation existed between change in peak oxygen consumption and change in peak arterial-venous oxygen difference (rZ.507; P<.05), but not with cardiac output. Change in peak oxygen consumption did not strongly correlate with change in function. Conclusions: Exercise induced peripheral muscle, but not cardiac output, adaptations after stroke. Implications for stroke clinical care should be explored further in a broader cohort.
Original languageEnglish
Pages (from-to)596-603
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Issue number4
Early online date4 Jan 2016
Publication statusPublished - Apr 2016
Externally publishedYes

Bibliographical note

c. 2016 by the American Congress of Rehabilitation Medicine. Published by Elsevier Inc. This is an open access article under the CC BY license


  • Cardiac ouput
  • Exercise
  • Physical fitness
  • Rehabilitation
  • Stroke


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