Exercise Induces Peripheral Muscle But Not Cardiac Adaptations After Stroke: A Randomized Controlled Pilot Trial

SA Moore, DG Jakovljevic, GA Ford, L Rochester, MI Trenell

Research output: Contribution to journalArticle

6 Citations (Scopus)
5 Downloads (Pure)

Abstract

Objective: To explore the physiological factors affecting exercise-induced changes in peak oxygen consumption and function poststroke. Design: Single-center, single-blind, randomized controlled pilot trial. Setting: Community stroke services. Participants: Adults (NZ40; age>50y; independent with/without stick) with stroke (diagnosed >6mo previously) were recruited from 117 eligible participants. Twenty participants were randomized to the intervention group and 20 to the control group. No dropouts or adverse events were reported. Interventions: Intervention group: 19-week (3times/wk) progressive mixed (aerobic/strength/balance/flexibility) community group exercise program. Control group: Matched duration home stretching program. Main Outcome Measures: (1) Pre- and postintervention: maximal cardiopulmonary exercise testing with noninvasive (bioreactance) cardiac output measurements; and (2) functional outcome measures: 6-minute walk test; timed Up and Go test, and Berg Balance Scale. Results: Exercise improved peak oxygen consumption (185 to 215mL/(kg,min); P<.01) and peak arterial-venous oxygen difference (9.22.7 to 11.42.9mL of O2/100mL of blood; P<.01), but did not alter cardiac output (17.24 to 17.74.2L/min; PZ.44) or cardiac power output (4.81.3 to 5.01.35W; PZ.45). A significant relation existed between change in peak oxygen consumption and change in peak arterial-venous oxygen difference (rZ.507; P<.05), but not with cardiac output. Change in peak oxygen consumption did not strongly correlate with change in function. Conclusions: Exercise induced peripheral muscle, but not cardiac output, adaptations after stroke. Implications for stroke clinical care should be explored further in a broader cohort.
Original languageEnglish
Pages (from-to)596-603
Number of pages8
JournalArchives of Physical Medicine and Rehabilitation
Volume97
Issue number4
Early online date4 Jan 2016
DOIs
Publication statusPublished - Apr 2016
Externally publishedYes

Bibliographical note

c. 2016 by the American Congress of Rehabilitation Medicine. Published by Elsevier Inc. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).

Keywords

  • Cardiac ouput
  • Exercise
  • Physical fitness
  • Rehabilitation
  • Stroke

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