Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease

Nathan D'Cunha, Andrew McKune, Demosthenes Panagiotakos, Ekavi Georgouspoulou, Jackson Thomas, Duane Mellor, Nenad Naumovski

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Abstract

There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer’s disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalNutritional Neuroscience
Volume22
Issue number1
Early online date11 Jul 2017
DOIs
Publication statusPublished - 2019

Bibliographical note

This is an Accepted Manuscript of an article published by Taylor & Francis in Nutritional Neuroscience on 11th July 2017, available online: http://www.tandfonline.com/10.1080/1028415X.2017.1349032

Keywords

  • S100B
  • Alzheimer's disease
  • Insulin
  • Ketogenic diet
  • Botanicals
  • Nutrition
  • Ageing
  • Apolipoprotein E
  • APOE4

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    D'Cunha, N., McKune, A., Panagiotakos, D., Georgouspoulou, E., Thomas, J., Mellor, D., & Naumovski, N. (2019). Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease. Nutritional Neuroscience, 22(1), 1-18. https://doi.org/10.1080/1028415X.2017.1349032