Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease

Nathan  D'Cunha; Andrew McKune; Demosthenes Panagiotakos; Ekavi Georgouspoulou; Jackson Thomas; Duane Mellor; Nenad Naumovski

doi:10.1080/1028415X.2017.1349032

Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease

Nathan D'Cunha, Andrew McKune, Demosthenes Panagiotakos, Ekavi Georgouspoulou, Jackson Thomas, Duane Mellor, Nenad Naumovski

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

112 Downloads (Pure)

Abstract

There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer’s disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk.

Original language	English
Pages (from-to)	1-18
Number of pages	18
Journal	Nutritional Neuroscience
Volume	22
Issue number	1
Early online date	11 Jul 2017
DOIs	https://doi.org/10.1080/1028415X.2017.1349032
Publication status	Published - 2019

Bibliographical note

This is an Accepted Manuscript of an article published by Taylor & Francis in Nutritional Neuroscience on 11th July 2017, available online: http://www.tandfonline.com/10.1080/1028415X.2017.1349032

Keywords

S100B
Alzheimer's disease
Insulin
Ketogenic diet
Botanicals
Nutrition
Ageing
Apolipoprotein E
APOE4

Access to Document

10.1080/1028415X.2017.1349032

Post-PrintAccepted author manuscript, 969 KB

Cite this

@article{92d19fc74e404956aacd372cd4b2efa0,

title = "Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease",

abstract = "There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer{\textquoteright}s disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk.",

keywords = "S100B, Alzheimer's disease, Insulin, Ketogenic diet, Botanicals, Nutrition, Ageing, Apolipoprotein E, APOE4",

author = "Nathan D'Cunha and Andrew McKune and Demosthenes Panagiotakos and Ekavi Georgouspoulou and Jackson Thomas and Duane Mellor and Nenad Naumovski",

note = "This is an Accepted Manuscript of an article published by Taylor & Francis in Nutritional Neuroscience on 11th July 2017, available online: http://www.tandfonline.com/10.1080/1028415X.2017.1349032 ",

year = "2019",

doi = "10.1080/1028415X.2017.1349032",

language = "English",

volume = "22",

pages = "1--18",

journal = "Nutritional Neuroscience",

issn = "1028-415X",

publisher = "Maney Publishing",

number = "1",

}

TY - JOUR

T1 - Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease

AU - D'Cunha, Nathan

AU - McKune, Andrew

AU - Panagiotakos, Demosthenes

AU - Georgouspoulou, Ekavi

AU - Thomas, Jackson

AU - Mellor, Duane

AU - Naumovski, Nenad

N1 - This is an Accepted Manuscript of an article published by Taylor & Francis in Nutritional Neuroscience on 11th July 2017, available online: http://www.tandfonline.com/10.1080/1028415X.2017.1349032

PY - 2019

Y1 - 2019

N2 - There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer’s disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk.

AB - There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer’s disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk.

KW - S100B

KW - Alzheimer's disease

KW - Insulin

KW - Ketogenic diet

KW - Botanicals

KW - Nutrition

KW - Ageing

KW - Apolipoprotein E

KW - APOE4

UR - http://www.scopus.com/inward/record.url?scp=85057550253&partnerID=8YFLogxK

U2 - 10.1080/1028415X.2017.1349032

DO - 10.1080/1028415X.2017.1349032

M3 - Article

SN - 1028-415X

SN - 1476-8305

VL - 22

SP - 1

EP - 18

JO - Nutritional Neuroscience

JF - Nutritional Neuroscience

IS - 1

ER -

Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this