Evaluation of a protocol-based intervention to promote timely switching from intravenous to oral paracetamol for post-operative pain management: an interrupted time series analysis

N. Sabry, D. Dawoud, A. Alansary, N. Hounsome, Darrin Baines

    Research output: Contribution to journalArticle

    5 Citations (Scopus)
    4 Downloads (Pure)

    Abstract

    Rationale, aims and objectives: Timely switching from intravenous to oral therapy ensures optimized treatment and efficient use of health care resources. Intravenous (IV) paracetamol is widely used for post-operative pain management but not always switched to the oral form in a timely manner, leading to unnecessary increase in expenditure. This study aims to evaluate the impact of a multifaceted intervention to promote timely switching from the IV to oral form in the post-operative setting. Methods: An evidence-based prescribing protocol was designed and implemented by the clinical pharmacy team in a single district general hospital in Egypt. The protocol specified the criteria for appropriate prescribing of IV paracetamol. Doctors were provided with information and educational sessions prior to implementation. A prospective, quasi-experimental study was undertaken to evaluate its impact on IV paracetamol utilization and costs. Data on monthly utilization and costs were recorded for 12 months before and after implementation (January 2012 to December 2013). Data were analysed using interrupted time series analysis. Results: Prior to implementation, in 2012, total spending on IV paracetamol was 674 154.00 Egyptian Pounds (L.E.) ($23 668.00). There was a non-significant (P > 0.05) downward trend in utilization (−32 ampoules per month) and costs [reduction of 632 L.E. ($222) per month]. Following implementation, immediate decrease in utilization and costs (P 
    Original languageEnglish
    Pages (from-to)1081-1088
    JournalJournal of Evaluation in Clinical Practice
    Volume21
    Issue number6
    DOIs
    Publication statusPublished - 22 Oct 2015

    Bibliographical note

    This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Evaluation in Clinical Practice on 22nd October 2015, available online: http://www.tandfonline.com/10.1111/jep.12463

    Keywords

    • evaluation
    • health economics
    • interrupted time series
    • IV-to-oral
    • paracetamol

    Fingerprint Dive into the research topics of 'Evaluation of a protocol-based intervention to promote timely switching from intravenous to oral paracetamol for post-operative pain management: an interrupted time series analysis'. Together they form a unique fingerprint.

  • Cite this