Endothelial Dysfunction and Coronary Artery Disease: A State of the Art Review

Murugapathy Veerasamy, Alan Bagnall, Dermot Neely, John Allen, Hannah Sinclair, Vijay Kunadian

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Atherosclerotic coronary artery disease (CAD) is a major cause of morbidity and mortality in the developed world. Endothelial dysfunction plays an important role in the development of atherosclerosis and predicts cardiovascular (CV) outcomes independent of conventional CV risk factors. In recent years, there have been tremendous improvements in the pharmacological prevention and management of CAD. In this review, the pathophysiology of endothelial dysfunction in relation to CAD is discussed and various techniques of invasive and noninvasive assessments of peripheral and coronary endothelial function described. In addition, evidence for the association of endothelial dysfunction and CV outcomes has been examined and finally the role of therapeutic interventions in endothelial dysfunction has been discussed.
Original languageEnglish
Pages (from-to)119-129
Number of pages11
JournalCardiology in Review
Issue number3
Publication statusPublished - 31 Dec 2015
Externally publishedYes


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