EN2: A candidate antigen for the development of targeted therapies in ovarian cancer.

Shadi Bokaee, A. Michael, C. Riley, M. Denyer, H. S. Pandha, N. E. Annels

Research output: Contribution to journalArticle

Abstract

Ovarian cancer remains the most lethal gynaecologic tumour in the Western world. Stimulation of the immune system to consolidate response to chemotherapy can potentially be beneficial however so far none of the vaccination strategies have offered survival advantage. Thus identifying and targeting clinically relevant antigens for immunotherapy continues to be an important research strategy. We have evaluated Engrailed-2 (EN2) as a potential target for vaccine strategy. EN2 is a homeodomain-containing transcription factor with a multifunctional role in neural development. There is evidence that over-expression of EN2 protein maybe linked to tumour development.
Original languageEnglish
JournalJournal of Clinical Oncology
Volume29
Issue number15_suppl
DOIs
Publication statusPublished - 20 May 2011

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Ovarian Neoplasms
Antigens
Western World
Immunotherapy
Immune System
Neoplasms
Vaccination
Transcription Factors
Vaccines
Drug Therapy
Therapeutics
Research
engrailed 2 protein

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EN2 : A candidate antigen for the development of targeted therapies in ovarian cancer. / Bokaee, Shadi; Michael, A.; Riley, C.; Denyer, M.; Pandha, H. S.; Annels, N. E.

In: Journal of Clinical Oncology, Vol. 29, No. 15_suppl, 20.05.2011.

Research output: Contribution to journalArticle

Bokaee, Shadi ; Michael, A. ; Riley, C. ; Denyer, M. ; Pandha, H. S. ; Annels, N. E. / EN2 : A candidate antigen for the development of targeted therapies in ovarian cancer. In: Journal of Clinical Oncology. 2011 ; Vol. 29, No. 15_suppl.
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