Abstract
The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 165-166 |
| Journal | Journal of Molecular Graphics |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1987 |
| Externally published | Yes |
Keywords
- lectrostatic potential
- DNA
- solid modelling
- anti-cancer drugs
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Burridge, J. M., Quarendon, P., Reynolds, C. A., & Goodford, P. J. (1987). Electrostatic potential and binding of drugs to the minor groove of DNA. Journal of Molecular Graphics, 5(3), 165-166. https://doi.org/10.1016/0263-7855(87)80066-8