Electrostatic potential and binding of drugs to the minor groove of DNA

J.M. Burridge; P. Quarendon; C.A. Reynolds; P.J. Goodford

doi:10.1016/0263-7855(87)80066-8

Electrostatic potential and binding of drugs to the minor groove of DNA

J.M. Burridge, P. Quarendon, C.A. Reynolds, P.J. Goodford

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.

Original language	English
Pages (from-to)	165-166
Journal	Journal of Molecular Graphics
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/0263-7855(87)80066-8
Publication status	Published - Sep 1987
Externally published	Yes

Keywords

lectrostatic potential
DNA
solid modelling
anti-cancer drugs

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10.1016/0263-7855(87)80066-8

http://www.scopus.com/inward/record.url?eid=2-s2.0-45949116617&partnerID=MN8TOARS

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title = "Electrostatic potential and binding of drugs to the minor groove of DNA",

abstract = "The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.",

keywords = "lectrostatic potential, DNA, solid modelling, anti-cancer drugs",

author = "J.M. Burridge and P. Quarendon and C.A. Reynolds and P.J. Goodford",

year = "1987",

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T1 - Electrostatic potential and binding of drugs to the minor groove of DNA

AU - Burridge, J.M.

AU - Quarendon, P.

AU - Reynolds, C.A.

AU - Goodford, P.J.

PY - 1987/9

Y1 - 1987/9

N2 - The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.

AB - The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.

KW - lectrostatic potential

KW - DNA

KW - solid modelling

KW - anti-cancer drugs

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-45949116617&partnerID=MN8TOARS

U2 - 10.1016/0263-7855(87)80066-8

DO - 10.1016/0263-7855(87)80066-8

M3 - Article

VL - 5

SP - 165

EP - 166

JO - Journal of Molecular Graphics and Modelling

JF - Journal of Molecular Graphics and Modelling

SN - 1093-3263

IS - 3

ER -