Electrostatic potential and binding of drugs to the minor groove of DNA

J.M. Burridge, P. Quarendon, C.A. Reynolds, P.J. Goodford

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.

Original languageEnglish
Pages (from-to)165-166
JournalJournal of Molecular Graphics
Volume5
Issue number3
DOIs
Publication statusPublished - Sep 1987
Externally publishedYes

Keywords

  • lectrostatic potential
  • DNA
  • solid modelling
  • anti-cancer drugs

Fingerprint Dive into the research topics of 'Electrostatic potential and binding of drugs to the minor groove of DNA'. Together they form a unique fingerprint.

  • Cite this