Abstract
The use of solid constructive geometry and color coding of electrostatic potential provides a clear distinction between the minor grooves of DNA with distinct sequences. The predicted differential binding of oxidized and reduced forms of ligands to the DNA grooves is proposed as a means of introducing tumor selectivity.
Original language | English |
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Pages (from-to) | 165-166 |
Journal | Journal of Molecular Graphics |
Volume | 5 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sep 1987 |
Externally published | Yes |
Keywords
- lectrostatic potential
- DNA
- solid modelling
- anti-cancer drugs