Electrospun polyurethane-core and gelatin-shell coaxial fibre coatings for miniature implantable biosensors

Ning Wang, Krishna Burugapalli, Shavini Wijesuriya, Mahshid Yazdi Far, Wenhui Song, Francis Moussy, Yudong Zheng, Yanxuan Ma, Zhentao Wu, Kang Li

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of this study was to introduce bioactivity to the electrospun coating for implantable glucose biosensors. Coaxial fibre membranes having polyurethane as the core and gelatin as the shell were produced using a range of polyurethane concentrations (2, 4, 6 and 8% wt/v) while keeping gelatin concentration (10% wt/v) constant in 2,2,2-trifluoroethanol. The gelatin shell was stabilized using glutaraldehyde vapour. The formation of core–shell structure was confirmed using transmission/scanning electron microscopy and FTIR. The coaxial fibre membranes showed uniaxial tensile properties intermediate to that of the pure polyurethane and the gelatin fibre membranes. The gelatin shell increased hydrophilicity and glucose transport flux across the coaxial fibre membranes. The coaxial fibre membranes having small fibre diameter (541 nm) and a thick gelatin shell (52%) did not affect the sensor sensitivity, but decreased sensor's linearity in the long run. In contrast, thicker coaxial fibre membranes (1133 nm) having a thin gelatin shell (34%) maintained both sensitivity and linearity for the 84 days of the study period. To conclude, polyurethane-gelatin coaxial fibre membranes, due to their faster permeability to glucose, tailorable mechanical properties and bioactivity, are potential candidates for coatings to favourably modify the host responses to extend the reliable in vivo lifetime of implantable glucose biosensors.
Original languageEnglish
Article number015002
JournalBiofabrication
Volume6
Issue number1
DOIs
Publication statusPublished - 17 Dec 2013

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Polyurethanes
Biosensing Techniques
Gelatin
Biosensors
Coatings
Membranes
Fibers
Glucose
Bioactivity
Trifluoroethanol
Scanning Transmission Electron Microscopy
Sensors
Hydrophilicity
Glutaral
Fourier Transform Infrared Spectroscopy
Hydrophobic and Hydrophilic Interactions
Tensile properties
Permeability
Vapors
Fluxes

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Electrospun polyurethane-core and gelatin-shell coaxial fibre coatings for miniature implantable biosensors. / Wang, Ning; Burugapalli, Krishna; Wijesuriya, Shavini; Yazdi Far, Mahshid; Song, Wenhui; Moussy, Francis; Zheng, Yudong; Ma, Yanxuan ; Wu, Zhentao; Li, Kang .

In: Biofabrication, Vol. 6, No. 1, 015002, 17.12.2013.

Research output: Contribution to journalArticle

Wang, N, Burugapalli, K, Wijesuriya, S, Yazdi Far, M, Song, W, Moussy, F, Zheng, Y, Ma, Y, Wu, Z & Li, K 2013, 'Electrospun polyurethane-core and gelatin-shell coaxial fibre coatings for miniature implantable biosensors' Biofabrication, vol. 6, no. 1, 015002. https://doi.org/10.1088/1758-5082/6/1/015002
Wang, Ning ; Burugapalli, Krishna ; Wijesuriya, Shavini ; Yazdi Far, Mahshid ; Song, Wenhui ; Moussy, Francis ; Zheng, Yudong ; Ma, Yanxuan ; Wu, Zhentao ; Li, Kang . / Electrospun polyurethane-core and gelatin-shell coaxial fibre coatings for miniature implantable biosensors. In: Biofabrication. 2013 ; Vol. 6, No. 1.
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abstract = "The aim of this study was to introduce bioactivity to the electrospun coating for implantable glucose biosensors. Coaxial fibre membranes having polyurethane as the core and gelatin as the shell were produced using a range of polyurethane concentrations (2, 4, 6 and 8{\%} wt/v) while keeping gelatin concentration (10{\%} wt/v) constant in 2,2,2-trifluoroethanol. The gelatin shell was stabilized using glutaraldehyde vapour. The formation of core–shell structure was confirmed using transmission/scanning electron microscopy and FTIR. The coaxial fibre membranes showed uniaxial tensile properties intermediate to that of the pure polyurethane and the gelatin fibre membranes. The gelatin shell increased hydrophilicity and glucose transport flux across the coaxial fibre membranes. The coaxial fibre membranes having small fibre diameter (541 nm) and a thick gelatin shell (52{\%}) did not affect the sensor sensitivity, but decreased sensor's linearity in the long run. In contrast, thicker coaxial fibre membranes (1133 nm) having a thin gelatin shell (34{\%}) maintained both sensitivity and linearity for the 84 days of the study period. To conclude, polyurethane-gelatin coaxial fibre membranes, due to their faster permeability to glucose, tailorable mechanical properties and bioactivity, are potential candidates for coatings to favourably modify the host responses to extend the reliable in vivo lifetime of implantable glucose biosensors.",
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AB - The aim of this study was to introduce bioactivity to the electrospun coating for implantable glucose biosensors. Coaxial fibre membranes having polyurethane as the core and gelatin as the shell were produced using a range of polyurethane concentrations (2, 4, 6 and 8% wt/v) while keeping gelatin concentration (10% wt/v) constant in 2,2,2-trifluoroethanol. The gelatin shell was stabilized using glutaraldehyde vapour. The formation of core–shell structure was confirmed using transmission/scanning electron microscopy and FTIR. The coaxial fibre membranes showed uniaxial tensile properties intermediate to that of the pure polyurethane and the gelatin fibre membranes. The gelatin shell increased hydrophilicity and glucose transport flux across the coaxial fibre membranes. The coaxial fibre membranes having small fibre diameter (541 nm) and a thick gelatin shell (52%) did not affect the sensor sensitivity, but decreased sensor's linearity in the long run. In contrast, thicker coaxial fibre membranes (1133 nm) having a thin gelatin shell (34%) maintained both sensitivity and linearity for the 84 days of the study period. To conclude, polyurethane-gelatin coaxial fibre membranes, due to their faster permeability to glucose, tailorable mechanical properties and bioactivity, are potential candidates for coatings to favourably modify the host responses to extend the reliable in vivo lifetime of implantable glucose biosensors.

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