Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review

Saleh  Rahmati; Behnam  Mohammadi; Zahra  Karimi-Mehr; David Robert Broom

doi:10.1002/cbf.3877

Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review

Saleh Rahmati
, Behnam Mohammadi
, Zahra Karimi-Mehr
, David Robert Broom

Islamic Azad University

Research output: Contribution to journal › Review article › peer-review

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Abstract

The aim of this rapid review is to examine the research evidence that presents the effects of physical activity and exercise on Nucleobindin‐2 (NUCB2) gene expression and Nesfatin‐1 concentration. Five databases (PubMed, Science Direct, Springer, Wiley, and Google Scholar) were searched for eligible studies from the earliest available date to August 2023. In human studies, Nesfatin‐1 concentration either remains unchanged or increases after exercise training. It appears that higher exercise intensity and longer duration of training accentuate the increase of blood Nesfatin‐1 concentration. The few human studies that have examined the acute response of exercise on Nesfatin‐1 concentration from blood draws show conflicting results. There is a severe lack of biopsy studies in humans which warrants attention. All published animal studies have used the mouse model. The majority show that regular exercise training increases tissue NUCB2/Nesfatin‐1. In some animal studies, where the effects of exercise on tissue Nesfatin‐1 concentration has been seen as significant, there has been no significant effect of exercise on plasma Nesfatin‐1 concentration. All animal studies evaluated the effect of endurance training except one which used resistance training. No animal studies have investigated the effects of acute exercise, which warrants investigation. In conclusion, human and animal studies have shown that physical training can increase NUCB2/Nesfatin‐1, but research evidence examining the effect of acute exercise is in its infancy. In addition, future comparative studies are needed to compare the effects of different training protocols on NUCB2/Nesfatin‐1 in humans and animals.

Original language	English
Pages (from-to)	1016-1030
Number of pages	15
Journal	Cell Biochemistry and Function
Volume	41
Issue number	8
Early online date	1 Nov 2023
DOIs	https://doi.org/10.1002/cbf.3877
Publication status	Published - 12 Dec 2023

Bibliographical note

This is the peer reviewed version of the following article: Rahmati, S, Mohammadi, B, Karimi-Mehr, Z & Broom, DR 2023, 'Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review', Cell Biochemistry and Function, vol. 41, no. 8, pp. 1016-1030., which has been published in final form at https://doi.org/10.1002/cbf.3877.

This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Keywords

exercise
Nesfatin‐1
Nucleobindin‐2 (NUCB2)
physical activity

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Cell Biology

Access to Document

10.1002/cbf.3877

Broom2023AAMAccepted author manuscript, 1.83 MB

Cite this

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abstract = "The aim of this rapid review is to examine the research evidence that presents the effects of physical activity and exercise on Nucleobindin‐2 (NUCB2) gene expression and Nesfatin‐1 concentration. Five databases (PubMed, Science Direct, Springer, Wiley, and Google Scholar) were searched for eligible studies from the earliest available date to August 2023. In human studies, Nesfatin‐1 concentration either remains unchanged or increases after exercise training. It appears that higher exercise intensity and longer duration of training accentuate the increase of blood Nesfatin‐1 concentration. The few human studies that have examined the acute response of exercise on Nesfatin‐1 concentration from blood draws show conflicting results. There is a severe lack of biopsy studies in humans which warrants attention. All published animal studies have used the mouse model. The majority show that regular exercise training increases tissue NUCB2/Nesfatin‐1. In some animal studies, where the effects of exercise on tissue Nesfatin‐1 concentration has been seen as significant, there has been no significant effect of exercise on plasma Nesfatin‐1 concentration. All animal studies evaluated the effect of endurance training except one which used resistance training. No animal studies have investigated the effects of acute exercise, which warrants investigation. In conclusion, human and animal studies have shown that physical training can increase NUCB2/Nesfatin‐1, but research evidence examining the effect of acute exercise is in its infancy. In addition, future comparative studies are needed to compare the effects of different training protocols on NUCB2/Nesfatin‐1 in humans and animals.",

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author = "Saleh Rahmati and Behnam Mohammadi and Zahra Karimi-Mehr and Broom, \{David Robert\}",

note = "This is the peer reviewed version of the following article: Rahmati, S, Mohammadi, B, Karimi-Mehr, Z \& Broom, DR 2023, 'Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review', Cell Biochemistry and Function, vol. 41, no. 8, pp. 1016-1030., which has been published in final form at https://doi.org/10.1002/cbf.3877. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley{\textquoteright}s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. This document is the author{\textquoteright}s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it. ",

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N2 - The aim of this rapid review is to examine the research evidence that presents the effects of physical activity and exercise on Nucleobindin‐2 (NUCB2) gene expression and Nesfatin‐1 concentration. Five databases (PubMed, Science Direct, Springer, Wiley, and Google Scholar) were searched for eligible studies from the earliest available date to August 2023. In human studies, Nesfatin‐1 concentration either remains unchanged or increases after exercise training. It appears that higher exercise intensity and longer duration of training accentuate the increase of blood Nesfatin‐1 concentration. The few human studies that have examined the acute response of exercise on Nesfatin‐1 concentration from blood draws show conflicting results. There is a severe lack of biopsy studies in humans which warrants attention. All published animal studies have used the mouse model. The majority show that regular exercise training increases tissue NUCB2/Nesfatin‐1. In some animal studies, where the effects of exercise on tissue Nesfatin‐1 concentration has been seen as significant, there has been no significant effect of exercise on plasma Nesfatin‐1 concentration. All animal studies evaluated the effect of endurance training except one which used resistance training. No animal studies have investigated the effects of acute exercise, which warrants investigation. In conclusion, human and animal studies have shown that physical training can increase NUCB2/Nesfatin‐1, but research evidence examining the effect of acute exercise is in its infancy. In addition, future comparative studies are needed to compare the effects of different training protocols on NUCB2/Nesfatin‐1 in humans and animals.

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Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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