Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial

Nazila Garousi, Babak Tamizifar, Makan Pourmasoumi, Awat Feizi, Gholamreza Askari, Cain C T Clark, Mohammad Hasan Entezari

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    3 Citations (Scopus)
    24 Downloads (Pure)

    Abstract

    The aim of the study was to compare the effects of a lacto-ovo-vegetarian diet (LOV-D) vs. a standard weight-loss diet (SWL-D) on obese/overweight adults with NAFLD. Present randomised clinical trial recruited 75 overweight/obese adults with NAFLD, who were randomly assigned into LOV-D and SWL-D groups for 3 months. The LOV-D was designed based on eliminating meat, poultry, and fish; while including dairy products and eggs. The SWL-D was planned according to the standard food pyramid, which was free in all sources of food. Adherence to LOV-D significantly outperformed SWL-D in reducing levels of alanine aminotransferase (ALT), body weight, waist circumference, BMI, fasting blood sugar, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP). Furthermore, ultrasonography revealed a higher alleviation in NAFLD grade among LOV-D, compared with SWL-D. This study suggests that adherence to LOV-D for 3 months has beneficial effects on NAFLD improvement, anthropometric measures, glycaemic-related markers, and lipid profiles.

    Original languageEnglish
    Pages (from-to)(In-press)
    Number of pages9
    JournalArchives of Physiology and Biochemistry
    Volume(In-press)
    Early online date9 Mar 2021
    DOIs
    Publication statusE-pub ahead of print - 9 Mar 2021

    Bibliographical note

    This is an Accepted Manuscript version of the following article, accepted for publication in Archives of Physiology and Biochemistry, Garousi, N, Tamizifar, B, Pourmasoumi, M, Feizi, A, Askari, G, Clark, CCT & Entezari, MH 2021, 'Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial', Archives of Physiology and Biochemistry, vol. (In-press), pp. (In-press).

    It is deposited under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

    Keywords

    • Lacto-ovo-vegetarian diet
    • non-alcoholic fatty liver
    • randomised clinical trial
    • standard weight-loss diet

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

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