Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial

Nazila Garousi; Babak Tamizifar; Makan Pourmasoumi; Awat Feizi; Gholamreza Askari; Cain C T Clark; Mohammad Hasan Entezari

doi:10.1080/13813455.2021.1890128

Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial

Nazila Garousi, Babak Tamizifar, Makan Pourmasoumi, Awat Feizi, Gholamreza Askari, Cain C T Clark, Mohammad Hasan Entezari

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

523 Downloads (Pure)

Abstract

The aim of the study was to compare the effects of a lacto-ovo-vegetarian diet (LOV-D) vs. a standard weight-loss diet (SWL-D) on obese/overweight adults with NAFLD. Present randomised clinical trial recruited 75 overweight/obese adults with NAFLD, who were randomly assigned into LOV-D and SWL-D groups for 3 months. The LOV-D was designed based on eliminating meat, poultry, and fish; while including dairy products and eggs. The SWL-D was planned according to the standard food pyramid, which was free in all sources of food. Adherence to LOV-D significantly outperformed SWL-D in reducing levels of alanine aminotransferase (ALT), body weight, waist circumference, BMI, fasting blood sugar, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP). Furthermore, ultrasonography revealed a higher alleviation in NAFLD grade among LOV-D, compared with SWL-D. This study suggests that adherence to LOV-D for 3 months has beneficial effects on NAFLD improvement, anthropometric measures, glycaemic-related markers, and lipid profiles.

Original language	English
Pages (from-to)	975-983
Number of pages	9
Journal	Archives of Physiology and Biochemistry
Volume	129
Issue number	4
Early online date	9 Mar 2021
DOIs	https://doi.org/10.1080/13813455.2021.1890128
Publication status	E-pub ahead of print - 9 Mar 2021

Bibliographical note

This is an Accepted Manuscript version of the following article, accepted for publication in Archives of Physiology and Biochemistry, Garousi, N, Tamizifar, B, Pourmasoumi, M, Feizi, A, Askari, G, Clark, CCT & Entezari, MH 2021, 'Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial', Archives of Physiology and Biochemistry, vol. (In-press), pp. (In-press).

It is deposited under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

Funder

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The authors thank all the study participants. They are also grateful to the staff of Khorshid Hospital for their support and cooperation. Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Lacto-ovo-vegetarian diet
non-alcoholic fatty liver
randomised clinical trial
standard weight-loss diet

ASJC Scopus subject areas

Physiology
Physiology (medical)

Access to Document

10.1080/13813455.2021.1890128

Post-PrintAccepted author manuscript, 1.03 MBLicence: CC BY-NC-ND

Cite this

Garousi, N., Tamizifar, B., Pourmasoumi, M., Feizi, A., Askari, G., Clark, C. C. T., & Entezari, M. H. (2021). Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial. Archives of Physiology and Biochemistry, 129(4), 975-983. Advance online publication. https://doi.org/10.1080/13813455.2021.1890128

Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial. / Garousi, Nazila; Tamizifar, Babak; Pourmasoumi, Makan et al.
In: Archives of Physiology and Biochemistry, Vol. 129, No. 4, 09.03.2021, p. 975-983.

Research output: Contribution to journal › Review article › peer-review

Garousi, N, Tamizifar, B, Pourmasoumi, M, Feizi, A, Askari, G, Clark, CCT & Entezari, MH 2021, 'Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial', Archives of Physiology and Biochemistry, vol. 129, no. 4, pp. 975-983. https://doi.org/10.1080/13813455.2021.1890128

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abstract = "The aim of the study was to compare the effects of a lacto-ovo-vegetarian diet (LOV-D) vs. a standard weight-loss diet (SWL-D) on obese/overweight adults with NAFLD. Present randomised clinical trial recruited 75 overweight/obese adults with NAFLD, who were randomly assigned into LOV-D and SWL-D groups for 3 months. The LOV-D was designed based on eliminating meat, poultry, and fish; while including dairy products and eggs. The SWL-D was planned according to the standard food pyramid, which was free in all sources of food. Adherence to LOV-D significantly outperformed SWL-D in reducing levels of alanine aminotransferase (ALT), body weight, waist circumference, BMI, fasting blood sugar, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP). Furthermore, ultrasonography revealed a higher alleviation in NAFLD grade among LOV-D, compared with SWL-D. This study suggests that adherence to LOV-D for 3 months has beneficial effects on NAFLD improvement, anthropometric measures, glycaemic-related markers, and lipid profiles.",

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Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial

Abstract

Bibliographical note

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Keywords

ASJC Scopus subject areas

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