Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial

Nazila Garousi, Babak Tamizifar, Makan Pourmasoumi, Awat Feizi, Gholamreza Askari, Cain C T Clark, Mohammad Hasan Entezari

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    The aim of the study was to compare the effects of a lacto-ovo-vegetarian diet (LOV-D) vs. a standard weight-loss diet (SWL-D) on obese/overweight adults with NAFLD. Present randomised clinical trial recruited 75 overweight/obese adults with NAFLD, who were randomly assigned into LOV-D and SWL-D groups for 3 months. The LOV-D was designed based on eliminating meat, poultry, and fish; while including dairy products and eggs. The SWL-D was planned according to the standard food pyramid, which was free in all sources of food. Adherence to LOV-D significantly outperformed SWL-D in reducing levels of alanine aminotransferase (ALT), body weight, waist circumference, BMI, fasting blood sugar, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triacylglycerol (TG), cholesterol, low-density lipoprotein cholesterol (LDL-C), and systolic blood pressure (SBP). Furthermore, ultrasonography revealed a higher alleviation in NAFLD grade among LOV-D, compared with SWL-D. This study suggests that adherence to LOV-D for 3 months has beneficial effects on NAFLD improvement, anthropometric measures, glycaemic-related markers, and lipid profiles.

    Original languageEnglish
    Pages (from-to)(In-press)
    Number of pages9
    JournalArchives of Physiology and Biochemistry
    Volume(In-press)
    Early online date9 Mar 2021
    DOIs
    Publication statusE-pub ahead of print - 9 Mar 2021

    Keywords

    • Lacto-ovo-vegetarian diet
    • non-alcoholic fatty liver
    • randomised clinical trial
    • standard weight-loss diet

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

    Fingerprint Dive into the research topics of 'Effects of lacto-ovo-vegetarian diet vs. standard-weight-loss diet on obese and overweight adults with non-alcoholic fatty liver disease: a randomised clinical trial'. Together they form a unique fingerprint.

    Cite this