Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial

Lee Ingle; Richard Powell; Brian Begg; Stefan T Birkett; Simon Nichols; Stuart Ennis; Pritwish Banerjee; Rob Shave; Gordon McGregor

doi:10.1016/j.apmr.2024.03.002

Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial

Lee Ingle, Richard Powell, Brian Begg, Stefan T Birkett, Simon Nichols, Stuart Ennis, Pritwish Banerjee, Rob Shave, Gordon McGregor

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To compare the characteristics of "responders" and "non-responders" to 8-weeks of exercise training to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD).

DESIGN: Secondary analysis of data from the HIIT or MISS UK trial.

SETTING: Six outpatient National Health Service cardiac rehabilitation centers in the UK. In people with CAD attending cardiac rehabilitation, the HIIT or MISS UK trial reported that short-term, low-volume, high intensity interval training (HIIT) was more effective than moderate intensity steady state (MISS) exercise training for improving peak oxygen uptake (VO 2peak).

PARTICIPANTS: 382 participants with CAD (mean age: 58.8 ± 9.6 years; mean BMI: 29.0 ± 4.3 kg∙m -2).

MAIN OUTCOME MEASURES: We identified "responders" and "non-responders" based on a meaningful change in peak oxygen uptake, using two established methods. Key clinical, quality of life, and cardiopulmonary exercise test (CPET)-derived outcomes were compared between groups.

RESULTS: Responders were more likely to be younger (P<0.05), and demonstrate greater improvement in CPET-related outcomes e.g. oxygen uptake efficiency slope (OUES), ventilatory efficiency (VE/VCO 2 slope), and peak power output (all comparisons, P<0.001). Responders were more likely to observe improvements in quality of life (EQ-5D-5L; mean Δ 13.6 v mean Δ 9.4; P=0.045), and HDL-cholesterol (mean Δ 0.09 mmol.L -1 v mean Δ 0.04 mmol.L -1; P=0.004), compared to non-responders.

CONCLUSIONS: In people with CAD attending cardiac rehabilitation, "responders" to exercise training were more likely to be younger, and demonstrate greater improvements in health-related QoL and HDL-cholesterol.

Original language	English
Pages (from-to)	(In-Press)
Number of pages	26
Journal	Archives of Physical Medicine and Rehabilitation
Volume	(In-Press)
Early online date	16 Mar 2024
DOIs	https://doi.org/10.1016/j.apmr.2024.03.002
Publication status	E-pub ahead of print - 16 Mar 2024

Bibliographical note

This is a PDFfileofanarticle that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ©2024Published by Elsevier Inc. on behalf of the American Congress of Rehabilitation Medicine

Keywords

Exercise dose
Exercise prescription
HIIT
Heart disease
Intensity
Training volume

ASJC Scopus subject areas

Rehabilitation
Physical Therapy, Sports Therapy and Rehabilitation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.apmr.2024.03.002

Cite this

Ingle, L., Powell, R., Begg, B., Birkett, S. T., Nichols, S., Ennis, S., Banerjee, P., Shave, R., & McGregor, G. (2024). Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial. Archives of Physical Medicine and Rehabilitation, (In-Press), (In-Press). Advance online publication. https://doi.org/10.1016/j.apmr.2024.03.002

Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial. / Ingle, Lee; Powell, Richard; Begg, Brian et al.
In: Archives of Physical Medicine and Rehabilitation, Vol. (In-Press), 16.03.2024, p. (In-Press).

Research output: Contribution to journal › Article › peer-review

Ingle, L, Powell, R, Begg, B, Birkett, ST, Nichols, S, Ennis, S, Banerjee, P, Shave, R & McGregor, G 2024, 'Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial', Archives of Physical Medicine and Rehabilitation, vol. (In-Press), pp. (In-Press). https://doi.org/10.1016/j.apmr.2024.03.002

Ingle L, Powell R, Begg B, Birkett ST, Nichols S, Ennis S et al. Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial. Archives of Physical Medicine and Rehabilitation. 2024 Mar 16;(In-Press):(In-Press). Epub 2024 Mar 16. doi: 10.1016/j.apmr.2024.03.002

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AU - Ingle, Lee

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AU - Birkett, Stefan T

AU - Nichols, Simon

AU - Ennis, Stuart

AU - Banerjee, Pritwish

AU - Shave, Rob

AU - McGregor, Gordon

N1 - This is a PDFfileofanarticle that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ©2024Published by Elsevier Inc. on behalf of the American Congress of Rehabilitation Medicine

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N2 - OBJECTIVE: To compare the characteristics of "responders" and "non-responders" to 8-weeks of exercise training to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD).DESIGN: Secondary analysis of data from the HIIT or MISS UK trial.SETTING: Six outpatient National Health Service cardiac rehabilitation centers in the UK. In people with CAD attending cardiac rehabilitation, the HIIT or MISS UK trial reported that short-term, low-volume, high intensity interval training (HIIT) was more effective than moderate intensity steady state (MISS) exercise training for improving peak oxygen uptake (VO 2peak). PARTICIPANTS: 382 participants with CAD (mean age: 58.8 ± 9.6 years; mean BMI: 29.0 ± 4.3 kg∙m -2). MAIN OUTCOME MEASURES: We identified "responders" and "non-responders" based on a meaningful change in peak oxygen uptake, using two established methods. Key clinical, quality of life, and cardiopulmonary exercise test (CPET)-derived outcomes were compared between groups.RESULTS: Responders were more likely to be younger (P<0.05), and demonstrate greater improvement in CPET-related outcomes e.g. oxygen uptake efficiency slope (OUES), ventilatory efficiency (VE/VCO 2 slope), and peak power output (all comparisons, P<0.001). Responders were more likely to observe improvements in quality of life (EQ-5D-5L; mean Δ 13.6 v mean Δ 9.4; P=0.045), and HDL-cholesterol (mean Δ 0.09 mmol.L -1 v mean Δ 0.04 mmol.L -1; P=0.004), compared to non-responders. CONCLUSIONS: In people with CAD attending cardiac rehabilitation, "responders" to exercise training were more likely to be younger, and demonstrate greater improvements in health-related QoL and HDL-cholesterol.

AB - OBJECTIVE: To compare the characteristics of "responders" and "non-responders" to 8-weeks of exercise training to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD).DESIGN: Secondary analysis of data from the HIIT or MISS UK trial.SETTING: Six outpatient National Health Service cardiac rehabilitation centers in the UK. In people with CAD attending cardiac rehabilitation, the HIIT or MISS UK trial reported that short-term, low-volume, high intensity interval training (HIIT) was more effective than moderate intensity steady state (MISS) exercise training for improving peak oxygen uptake (VO 2peak). PARTICIPANTS: 382 participants with CAD (mean age: 58.8 ± 9.6 years; mean BMI: 29.0 ± 4.3 kg∙m -2). MAIN OUTCOME MEASURES: We identified "responders" and "non-responders" based on a meaningful change in peak oxygen uptake, using two established methods. Key clinical, quality of life, and cardiopulmonary exercise test (CPET)-derived outcomes were compared between groups.RESULTS: Responders were more likely to be younger (P<0.05), and demonstrate greater improvement in CPET-related outcomes e.g. oxygen uptake efficiency slope (OUES), ventilatory efficiency (VE/VCO 2 slope), and peak power output (all comparisons, P<0.001). Responders were more likely to observe improvements in quality of life (EQ-5D-5L; mean Δ 13.6 v mean Δ 9.4; P=0.045), and HDL-cholesterol (mean Δ 0.09 mmol.L -1 v mean Δ 0.04 mmol.L -1; P=0.004), compared to non-responders. CONCLUSIONS: In people with CAD attending cardiac rehabilitation, "responders" to exercise training were more likely to be younger, and demonstrate greater improvements in health-related QoL and HDL-cholesterol.

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KW - Exercise prescription

KW - HIIT

KW - Heart disease

KW - Intensity

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Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights from the HIIT or MISS UK trial

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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