Effects of Endurance Training with or without Rosehip Fruits (Rosa canina L) Extraction and D-galactose Solution on Plasmatic Liver Enzymes, Lipid Profiles, Selected Biochemical Variables in Male Rats

Abbass Ghanbari-Niaki, Saleh Rahmati-Ahmadabad, David Robert Broom, Ali-Akbar Kolbadinejad, Jamal Nikbakht, Martin Hofmeister

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    Abstract

    The aims of the present study were to examine the effects of D-galactose (DG) supplementation on plasma aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, albumin, urea, bilirubin, cholesterol, and triglyceride. We also investigated the effects of Rosehip (Rosa canina L) fruit extraction and endurance exercise training on DG-induced changes in the aforementioned variables in male rats. Eighty-six male rats were randomly assigned to 8 groups 1) Control Saline 2) Training Saline 3) Control D-galactose 4) Training D-galactose 5) Control Rosehip 6) Training Rosehip 7) Control combined group and 8) Training combined group. Animals received experiments on the base of groups’ names (eight weeks and five times per week). Seventy-two hours after the last training or control session plasma was collected. The results showed that endurance training significantly increased plasma albumin while reducing ALT and creatinine. Rosehip significantly reduced plasma AST, creatinine, urea, cholesterol, and triglyceride, and increased bilirubin. A combination of training and Rosehip causes an additive effect compared to each intervention alone on AST. The use of DG increased ALT, AST, ALP, creatinine, urea, bilirubin, cholesterol, and triglyceride, while decreasing albumin. The use of Rosehip in combination with DG was able to minimize DG-induced abnormal elevation on some variables. In conclusion, using a high dose of D-galactose solution or high galactose content foods could make a precondition background for the non-alcoholic fatty liver which could be attenuated by crud Rosehip extraction. Thus, it seems that the Rosehip can be considered a hepatoprotective herb.
    Original languageEnglish
    Article numbere22210460
    Number of pages14
    JournalBrazilian Archives of Biology and Technology
    Volume65
    Early online date24 Oct 2022
    DOIs
    Publication statusPublished - 2022

    Bibliographical note

    This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Keywords

    • Albumin
    • aminotransferase (AST)
    • bilirubin
    • cholesterol
    • creatinine
    • urea

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