Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: A randomized crossover trial

Ben Lee; Robert D Meade; Sarah L Davey; Charles D Thake; James J McCormick; Kelli E King; Glen P Kenny

doi:10.1139/apnm-2024-0368

Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: A randomized crossover trial

Ben Lee, Robert D Meade, Sarah L Davey, Charles D Thake, James J McCormick, Kelli E King, Glen P Kenny

Centre for Physical Activity, Sport and Exercise Sciences

University of Ottawa

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We evaluated enterocyte damage (IFABP), immune activation (sCD14), and inflammatory responses (TNF-α, IL-6, CRP) in 16 older adults (66–78 years) during 8 h rest in conditions simulating homes maintained at 22°C (control), the 26°C indoor temperature upper limit proposed by health agencies, and homes without air-conditioning during heatwaves (31°C, 36°C). Relative to 22°C, IFABP was elevated ~181 pg/mL after exposure to 31°C(P=0.07), and by ~378 pg/mL (P < 0.001) after exposure to 36°C. No differences were observed for sCD14, TNF-α, IL-6, or CRP (all P ≥ 0.26). Our data support recommendations to maintain indoor temperatures ≤ 26°C to preserve gastrointestinal barrier integrity in heat-vulnerable persons.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Applied Physiology, Nutrition, and Metabolism
Volume	50
Early online date	13 Mar 2025
DOIs	https://doi.org/10.1139/apnm-2024-0368
Publication status	E-pub ahead of print - 13 Mar 2025

Funding

This research was funded by the Canadian Institutes for Health Research (CIHR) Research Grant (No. 399434) and Health Canada (contract No. 4500387992; funds held by Glen P. Kenny). The funders had no role in trial design collection, analysis, or interpretation of data, or in manuscript development. No authors received direct compensation related to the development of this article. R.D.M was supported by the Canadian Institutes of Health Research and the Human and Environmental Physiology Research Unit. JJM and KEK were supported by Mitacs Accelerate and the Human and Environmental Physiology Research Unit.

Funders	Funder number
Human and Environmental Physiology Research Unit
Mitacs
Canadian Institutes of Health Research	399434
Canadian Institutes of Health Research
Health Canada	4500387992
Health Canada

Keywords

ageing
climate change
gastrointestinal barrier
heat waves
indoor temperature

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1139/apnm-2024-0368

Lee2025AAMAccepted author manuscript, 169 KB

Cite this

Lee, B., Meade, R. D., Davey, S. L., Thake, C. D., McCormick, J. J., King, K. E., & Kenny, G. P. (2025). Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: A randomized crossover trial. Applied Physiology, Nutrition, and Metabolism, 50, 1-7. Advance online publication. https://doi.org/10.1139/apnm-2024-0368

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abstract = "We evaluated enterocyte damage (IFABP), immune activation (sCD14), and inflammatory responses (TNF-α, IL-6, CRP) in 16 older adults (66–78 years) during 8 h rest in conditions simulating homes maintained at 22°C (control), the 26°C indoor temperature upper limit proposed by health agencies, and homes without air-conditioning during heatwaves (31°C, 36°C). Relative to 22°C, IFABP was elevated ~181 pg/mL after exposure to 31°C(P=0.07), and by ~378 pg/mL (P < 0.001) after exposure to 36°C. No differences were observed for sCD14, TNF-α, IL-6, or CRP (all P ≥ 0.26). Our data support recommendations to maintain indoor temperatures ≤ 26°C to preserve gastrointestinal barrier integrity in heat-vulnerable persons.",

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AU - Meade, Robert D

AU - Davey, Sarah L

AU - Thake, Charles D

AU - McCormick, James J

AU - King, Kelli E

AU - Kenny, Glen P

PY - 2025/3/13

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AB - We evaluated enterocyte damage (IFABP), immune activation (sCD14), and inflammatory responses (TNF-α, IL-6, CRP) in 16 older adults (66–78 years) during 8 h rest in conditions simulating homes maintained at 22°C (control), the 26°C indoor temperature upper limit proposed by health agencies, and homes without air-conditioning during heatwaves (31°C, 36°C). Relative to 22°C, IFABP was elevated ~181 pg/mL after exposure to 31°C(P=0.07), and by ~378 pg/mL (P < 0.001) after exposure to 36°C. No differences were observed for sCD14, TNF-α, IL-6, or CRP (all P ≥ 0.26). Our data support recommendations to maintain indoor temperatures ≤ 26°C to preserve gastrointestinal barrier integrity in heat-vulnerable persons.

KW - ageing

KW - climate change

KW - gastrointestinal barrier

KW - heat waves

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Effects of daylong exposure to indoor overheating on enterocyte damage and inflammatory responses in older adults: A randomized crossover trial

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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