Effects of bariatric surgery on retinal microvascular architecture in obese patients

Antti Viljanen, Minna Soinio, Carol Yim-Lui Cheung, Jarna C Hannukainen, Henry K Karlsson, Tien Yin Wong, Alun D Hughes, Paulina Salminen, Pirjo Nuutila, Eija Vesti, Robyn J Tapp

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

STUDY AIM: Retinal microvasculature changes reflect systemic small vessel damage from obesity. The impact of bariatric surgery induced weight loss on the microvasculature is relatively unknown. We hypothesized that weight loss following bariatric surgery would be associated with improved structural changes in the retinal microvasculature, reflecting an overall improvement in microvascular health.

METHODS: The study included 22 obese subjects scheduled for bariatric surgery (laparoscopic Roux-en-Y gastric bypass or a sleeve gastrectomy) and 15 lean, age-matched controls. Ophthalmic examination, including fundus photography, was performed at baseline and 6-months. Retinal microvasculature caliber was analysed quantitatively using a semi-automated computer program and summarized as central retinal artery equivalent (CRAE) and venular equivalent (CRVE).

RESULTS: Mean weight loss at 6 months was 26.1 kg ± 8 kg in the bariatric surgery group. Retinal artery caliber increased (136.0 ± 1.4 to 141.4 ± 1.4 µm, p = 0.013) and venular caliber decreased (202.9 ± 1.9 to 197.3 ± 1.9 µm, p = 0.046) in the bariatric surgery group by 6 months, with no change in arteriolar (136.6 ± 1.1 to 134.5 ± 1.2, p = 0.222) or venular (195.1 ± 2.1 to 193.3 ± 2.2, p = 0.550) caliber in the control group. The arteriolar to venular ratio increased in the bariatric surgery group, with no change in the control group at 6 months.

CONCLUSIONS: The findings suggest obesity-related microvascular changes are reversible after bariatric surgery-induced weight loss. The capacity for the retinal microvasculature to improve following bariatric surgery suggests plasticity of the human microvasculature early in the disease course.

Original languageEnglish
Pages (from-to)1675-1680
Number of pages6
JournalInternational Journal of Obesity
Volume43
Issue number9
DOIs
Publication statusPublished - 5 Dec 2018
Externally publishedYes

Keywords

  • Adult
  • Bariatric Surgery/statistics & numerical data
  • Female
  • Humans
  • Microvessels/pathology
  • Middle Aged
  • Obesity, Morbid/epidemiology
  • Prospective Studies
  • Retinal Vessels/pathology
  • Treatment Outcome
  • Weight Loss/physiology

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  • Cite this

    Viljanen, A., Soinio, M., Cheung, C. Y-L., Hannukainen, J. C., Karlsson, H. K., Wong, T. Y., ... Tapp, R. J. (2018). Effects of bariatric surgery on retinal microvascular architecture in obese patients. International Journal of Obesity, 43(9), 1675-1680. https://doi.org/10.1038/s41366-018-0242-7