Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments

Yue Zhang; Alison Davenport; Bernard Burke; Owen Addison; Nina Vyas

doi:10.1021/acsbiomaterials.7b00882

Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments

Yue Zhang, Alison Davenport, Bernard Burke, Owen Addison, Nina Vyas

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

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Abstract

The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and Reactive Oxygen Species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially-pure (CP) Ti, Zr and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility.
Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.

Original language	English
Pages (from-to)	1103-1111
Number of pages	9
Journal	ACS Biomaterials Science and Engineering
Volume	4
Issue number	3
Early online date	19 Feb 2018
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00882
Publication status	Published - 12 Mar 2018

Bibliographical note

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Biomaterials Science and Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acsbiomaterials.7b00882

Keywords

Biomaterials
Reactive Oxygen Species
Macrophages
Titanium
zirconium alloy

Access to Document

10.1021/acsbiomaterials.7b00882

Post-PrintAccepted author manuscript, 2.08 MB

Bernard Burke
- Centre for Health and Life Sciences - Associate Professor Research
Person: Teaching and Research

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title = "Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments",

abstract = "The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and Reactive Oxygen Species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially-pure (CP) Ti, Zr and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility.Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.",

keywords = "Biomaterials, Reactive Oxygen Species, Macrophages, Titanium, zirconium alloy",

author = "Yue Zhang and Alison Davenport and Bernard Burke and Owen Addison and Nina Vyas",

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AU - Zhang, Yue

AU - Davenport, Alison

AU - Burke, Bernard

AU - Addison, Owen

AU - Vyas, Nina

N1 - This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Biomaterials Science and Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acsbiomaterials.7b00882

PY - 2018/3/12

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N2 - The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and Reactive Oxygen Species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially-pure (CP) Ti, Zr and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility.Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.

AB - The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and Reactive Oxygen Species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially-pure (CP) Ti, Zr and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility.Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.

KW - Biomaterials

KW - Reactive Oxygen Species

KW - Macrophages

KW - Titanium

KW - zirconium alloy

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DO - 10.1021/acsbiomaterials.7b00882

M3 - Article

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JF - ACS Biomaterials Science and Engineering

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ER -

Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments

Abstract

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Keywords

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Bernard Burke

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