Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

Huaping Shang, Akshaya Srikanth Bhagavathu, Wafa Ali Aldhaleei, Jamal Rahmani, Giorgio Karam, Giulia Rinald, Cain Clark, Ammar Salehisahlabadi, Qian Yuan

Research output: Contribution to journalReview article

Abstract

Propolis is a resin-like substance collected by honeybees from certain plants that
have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August, 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): -17.96 pg/ml, 95% CI: -35.53, -0.38, I2 = 98%), (WMD: -1.16 pg/ml, 95% CI: -2.28, -0.03, I2 = 97%), and (WMD: -34.08 pg/ml, 95% CI: -60.25, -7.91, I2 = 97%), respectively. Propolis did not showed any significant effect on IL-1 (WMD: -17.36 pg/ml, 95% CI: -37.60, 2.87, I2 = 97%). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation.
Original languageEnglish
Pages (from-to)(In-Press)
Number of pages8
JournalJournal of King Saud University - Computer and Information Sciences
Volume(In-Press)
Early online date10 Jan 2020
DOIs
Publication statusE-pub ahead of print - 10 Jan 2020

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Resins
Proteins

Keywords

  • CRP
  • CRP: c-reactive protein
  • IL-1: Interleukin 1
  • IL-6: Interleukin 6
  • Inflammation
  • Interleukin-1
  • Interleukin-6
  • Propolis
  • TNF
  • TNF-a: Tumor necrosis factor alpha
  • WMD: Weighted mean differences

ASJC Scopus subject areas

  • General

Cite this

Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials. / Shang, Huaping ; Bhagavathu, Akshaya Srikanth ; Ali Aldhaleei, Wafa ; Rahmani, Jamal; Karam, Giorgio ; Rinald, Giulia ; Clark, Cain; Salehisahlabadi, Ammar ; Yuan, Qian .

In: Journal of King Saud University - Computer and Information Sciences, Vol. (In-Press), 10.01.2020, p. (In-Press).

Research output: Contribution to journalReview article

Shang, Huaping ; Bhagavathu, Akshaya Srikanth ; Ali Aldhaleei, Wafa ; Rahmani, Jamal ; Karam, Giorgio ; Rinald, Giulia ; Clark, Cain ; Salehisahlabadi, Ammar ; Yuan, Qian . / Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials. In: Journal of King Saud University - Computer and Information Sciences. 2020 ; Vol. (In-Press). pp. (In-Press).
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abstract = "Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August, 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): -17.96 pg/ml, 95{\%} CI: -35.53, -0.38, I2 = 98{\%}), (WMD: -1.16 pg/ml, 95{\%} CI: -2.28, -0.03, I2 = 97{\%}), and (WMD: -34.08 pg/ml, 95{\%} CI: -60.25, -7.91, I2 = 97{\%}), respectively. Propolis did not showed any significant effect on IL-1 (WMD: -17.36 pg/ml, 95{\%} CI: -37.60, 2.87, I2 = 97{\%}). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation.",
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author = "Huaping Shang and Bhagavathu, {Akshaya Srikanth} and {Ali Aldhaleei}, Wafa and Jamal Rahmani and Giorgio Karam and Giulia Rinald and Cain Clark and Ammar Salehisahlabadi and Qian Yuan",
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T1 - Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

AU - Shang, Huaping

AU - Bhagavathu, Akshaya Srikanth

AU - Ali Aldhaleei, Wafa

AU - Rahmani, Jamal

AU - Karam, Giorgio

AU - Rinald, Giulia

AU - Clark, Cain

AU - Salehisahlabadi, Ammar

AU - Yuan, Qian

PY - 2020/1/10

Y1 - 2020/1/10

N2 - Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August, 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): -17.96 pg/ml, 95% CI: -35.53, -0.38, I2 = 98%), (WMD: -1.16 pg/ml, 95% CI: -2.28, -0.03, I2 = 97%), and (WMD: -34.08 pg/ml, 95% CI: -60.25, -7.91, I2 = 97%), respectively. Propolis did not showed any significant effect on IL-1 (WMD: -17.36 pg/ml, 95% CI: -37.60, 2.87, I2 = 97%). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation.

AB - Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August, 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): -17.96 pg/ml, 95% CI: -35.53, -0.38, I2 = 98%), (WMD: -1.16 pg/ml, 95% CI: -2.28, -0.03, I2 = 97%), and (WMD: -34.08 pg/ml, 95% CI: -60.25, -7.91, I2 = 97%), respectively. Propolis did not showed any significant effect on IL-1 (WMD: -17.36 pg/ml, 95% CI: -37.60, 2.87, I2 = 97%). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation.

KW - CRP

KW - CRP: c-reactive protein

KW - IL-1: Interleukin 1

KW - IL-6: Interleukin 6

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KW - Interleukin-1

KW - Interleukin-6

KW - Propolis

KW - TNF

KW - TNF-a: Tumor necrosis factor alpha

KW - WMD: Weighted mean differences

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DO - 10.1016/j.jksus.2020.01.003

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JO - Journal of King Saud University - Computer and Information Sciences

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SN - 1319-1578

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