Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

Huaping  Shang; Akshaya Srikanth  Bhagavathu; Wafa  Ali Aldhaleei; Jamal Rahmani; Giorgio   Karam; Giulia  Rinald; Cain Clark; Ammar  Salehisahlabadi; Qian  Yuan

doi:10.1016/j.jksus.2020.01.003

Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

Huaping Shang, Akshaya Srikanth Bhagavathu, Wafa Ali Aldhaleei, Jamal Rahmani, Giorgio Karam, Giulia Rinald, Cain Clark, Ammar Salehisahlabadi, Qian Yuan

Research output: Contribution to journal › Review article › peer-review

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Abstract

Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August, 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): -17.96 pg/ml, 95% CI: -35.53, -0.38, I2 = 98%), (WMD: -1.16 pg/ml, 95% CI: -2.28, -0.03, I2 = 97%), and (WMD: -34.08 pg/ml, 95% CI: -60.25, -7.91, I2 = 97%), respectively. Propolis did not showed any significant effect on IL-1 (WMD: -17.36 pg/ml, 95% CI: -37.60, 2.87, I2 = 97%). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation.

Original language	English
Pages (from-to)	1694-1701
Number of pages	8
Journal	Journal of King Saud University - Computer and Information Sciences
Volume	32
Issue number	2
Early online date	10 Jan 2020
DOIs	https://doi.org/10.1016/j.jksus.2020.01.003
Publication status	Published - Mar 2020

Bibliographical note

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keywords

CRP
CRP: c-reactive protein
IL-1: Interleukin 1
IL-6: Interleukin 6
Inflammation
Interleukin-1
Interleukin-6
Propolis
TNF
TNF-a: Tumor necrosis factor alpha
WMD: Weighted mean differences

ASJC Scopus subject areas

General

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Shang, H., Bhagavathu, A. S., Ali Aldhaleei, W., Rahmani, J., Karam, G., Rinald, G., Clark, C., Salehisahlabadi, A., & Yuan, Q. (2020). Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials. Journal of King Saud University - Computer and Information Sciences, 32(2), 1694-1701. https://doi.org/10.1016/j.jksus.2020.01.003

Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials. / Shang, Huaping ; Bhagavathu, Akshaya Srikanth ; Ali Aldhaleei, Wafa et al.
In: Journal of King Saud University - Computer and Information Sciences, Vol. 32, No. 2, 03.2020, p. 1694-1701.

Research output: Contribution to journal › Review article › peer-review

Shang, H, Bhagavathu, AS, Ali Aldhaleei, W, Rahmani, J, Karam, G, Rinald, G, Clark, C, Salehisahlabadi, A & Yuan, Q 2020, 'Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials', Journal of King Saud University - Computer and Information Sciences, vol. 32, no. 2, pp. 1694-1701. https://doi.org/10.1016/j.jksus.2020.01.003

Shang H, Bhagavathu AS, Ali Aldhaleei W, Rahmani J, Karam G, Rinald G et al. Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials. Journal of King Saud University - Computer and Information Sciences. 2020 Mar;32(2):1694-1701. Epub 2020 Jan 10. doi: 10.1016/j.jksus.2020.01.003

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title = "Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials",

abstract = "Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis supplementation on CRP, TNF-a, IL-1, and IL-6 in Randomized Controlled Trials (RCTs). A comprehensive systematic search of articles was conducted in PubMed/MEDLINE, Web of sciences, and Scopus to identify the potential titles up to August, 2019. PRISMA guidelines were performed for this study. Inclusion was 1-study design was parallel or cross over randomized controlled trial (RCT), 2- consumption of Propolis as intervention, 3- reported sufficient information about inflammatory factors, CRP, IL1, IL6, TNF-a. Six studies were identified by comprehensive search. This meta-analysis study found a significant reduction in IL6, CRP, and TNF-α following Propolis consumption (Weighted mean differences (WMD): -17.96 pg/ml, 95% CI: -35.53, -0.38, I2 = 98%), (WMD: -1.16 pg/ml, 95% CI: -2.28, -0.03, I2 = 97%), and (WMD: -34.08 pg/ml, 95% CI: -60.25, -7.91, I2 = 97%), respectively. Propolis did not showed any significant effect on IL-1 (WMD: -17.36 pg/ml, 95% CI: -37.60, 2.87, I2 = 97%). In conclusion, the results demonstrated that CRP, TNF-a and IL-6 were significantly reduced following propolis supplementation. ",

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author = "Huaping Shang and Bhagavathu, {Akshaya Srikanth} and {Ali Aldhaleei}, Wafa and Jamal Rahmani and Giorgio Karam and Giulia Rinald and Cain Clark and Ammar Salehisahlabadi and Qian Yuan",

note = "This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).",

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T2 - A systematic review and meta-analysis of randomized controlled trials

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AU - Bhagavathu, Akshaya Srikanth

AU - Ali Aldhaleei, Wafa

AU - Rahmani, Jamal

AU - Karam, Giorgio

AU - Rinald, Giulia

AU - Clark, Cain

AU - Salehisahlabadi, Ammar

AU - Yuan, Qian

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KW - TNF-a: Tumor necrosis factor alpha

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JO - Journal of King Saud University - Computer and Information Sciences

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Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors: A systematic review and meta-analysis of randomized controlled trials

Abstract

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Keywords

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