Effect of multiple clinical factors on recurrent angina after percutaneous coronary intervention: A retrospective study from 398 ST-segment elevation myocardial infarction patients

J. Zhang, Chengyu Liu, C. Pan, M. Bai, Jin Zhang, Y. Peng, D. Zheng, Z. Zhang

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Abstract

Recurrent angina (RA) has an important influence on health status of patients after percutaneous coronary intervention (PCI). This study aimed to retrospectively investigate the effect of multiple clinical factors on both short-term and long-term development of RA.A total of 398 ST-segment elevation myocardial infarction (STEMI) patients were studied for up to 12 months. The primary clinicaloutcome, RA, was assessed at 1-month and 12-month. In multivariate analyses, the effect of clinical factors, including baseline demographics, medical history, infarction-related arteries, procedural characteristics of PCI, and the use of medicines, was investigated in patients with and without RA.The Logistic regression analysis showed that the patients with treatment through radial approach PCI (odds ratio [OR]: 0.42, 95%confidence interval [CI]: 0.18–0.96, P<0.05) were less likely to have RA during 1-month assessment. During 12 months after PCI,male patients (OR: 0.53, 95% CI: 0.29–0.96, P<0.05), and/or those treated with radial approach PCI (OR: 0.45, 95% CI: 0.21–0.97, P<0.05) were less likely to have RA, whereas the patients with infarction related artery (IRA) in left anterior descending (LAD) (OR: 2.41, 95% CI: 1.20–4.84, P<0.01) were more likely to have RA at follow-up. The Cox regression analysis further revealed that the patients with infarction of the LAD artery (hazard ratio [HR]: 2.08, 95% CI: 1.10–3.92, P<0.05), but not with treatment through radial artery during PCI (HR: 0.42, 95% CI: 0.18–0.96, P<0.05) had higher potential of development of RA during 12 months after PCI.We studied the effects of multiple clinical factors on the development of RA after PCI. Our findings suggest that patients with infarction of the LAD artery, and/or treatment not through radial artery during PCI were associated with higher risk of RA and may require close follow-up.Abbreviations: ACEI = angiotensin converting enzyme inhibitors, ACS = acute coronary syndrome, AMI = acute myocardialinfarction, ARB = angiotensin receptor blockers, CCB = calcium channel blockers, CHD = coronary heart disease, CI = confidenceinterval, DBP = diastolic blood pressure, DM = diabetes mellitus, HC = hypercholesterolemia, HR = hazard ratio, HTG =hypertriglyceridemia, IABP = intra-aortic balloon pump, IRA = infarction related artery, LAD = left anterior descending, LCX = leftcircumflex, OR = odds ratio, PCI = percutaneous coronary intervention, RA = recurrent angina, RCA = right coronary artery, SBP =systolic blood pressure,, SD = standard deviation, STEMI = ST-segment elevation myocardial infarction, TP = temporary pacing.
Original languageEnglish
Article numbere5015
Number of pages8
JournalMedicine
Volume95
Issue number41
DOIs
Publication statusPublished - Oct 2016
Externally publishedYes

Bibliographical note

Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NCND), where it is permissible to download and share the work provided it is properly cited. The work
cannot be changed in any way or used commercially without permission from the journal.

Keywords

  • Acute coronary syndrome (ACS)
  • Multiple clinical factor
  • Percutaneous coronary intervention (PCI)
  • Recurrent angina (RA)
  • Retrospective study
  • , ST-segment elevation myocardial infarction (STEMI)

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