Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome:  A randomized, placebo‐controlled clinical trial

Mahsa Gholizadeh‐Moghaddam; Hatav Ghasemi‐Tehrani; Gholamreza Askari; Mahsima Jaripur; Cain C. T. Clark; Mohammad Hossein Rouhani

doi:10.1002/hsr2.1013

Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo‐controlled clinical trial

Mahsa Gholizadeh‐Moghaddam, Hatav Ghasemi‐Tehrani, Gholamreza Askari, Mahsima Jaripur, Cain C. T. Clark, Mohammad Hossein Rouhani

Isfahan University of Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

288 Downloads (Pure)

Abstract

Background and Aims: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women, which causes numerous symptoms in women. The relationship of many micronutrients with this syndrome has been investigated. This study was conducted to examine the effects of magnesium supplementation on hyperandrogenism, hirsutism, and sleep quality in women with PCOS. Methods: In this parallel randomized clinical trial, 64 women with PCOS were randomly assigned to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. Patients in the magnesium group received one 250 mg magnesium oxide tablet, per day. Hyperandrogenism, hirsutism, and sleep quality were measured at the beginning and end of the study. This randomized clinical trial was registered at https://www.IRCT.ir (IRCT20130903014551N8). Results: Magnesium supplementation had no significant effect on hyperandrogenism (p = 0.51 for dehydroepiandrosterone sulfates, p = 0.27 for testosterone), hirsutism (p = 0.23), and sleep quality (p = 0.85) compared with placebo. Conclusions: The present study showed that a single dose of magnesium supplementation elicited no beneficial effects on the mentioned symptoms in polycystic women. It is possible that the positive effects of magnesium observed in the former studies were due to the synergistic effects of other vitamins or minerals. More studies are needed in this area.

Original language	English
Article number	e1013
Number of pages	8
Journal	Health Science Reports
Volume	6
Issue number	1
Early online date	29 Dec 2022
DOIs	https://doi.org/10.1002/hsr2.1013
Publication status	Published - Jan 2023

Bibliographical note

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.© 2022 The Authors.Health Science Reportspublished by Wiley Periodicals LLC.

Keywords

hirsutism
hyperandrogenism
magnesium
polycystic ovarian syndrome
sleep quality

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PublishedFinal published version, 1.43 MBLicence: CC BY
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Cite this

Gholizadeh‐Moghaddam, M., Ghasemi‐Tehrani, H., Askari, G., Jaripur, M., Clark, C. C. T., & Rouhani, M. H. (2023). Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo‐controlled clinical trial. Health Science Reports, 6(1), Article e1013. https://doi.org/10.1002/hsr2.1013

Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo‐controlled clinical trial. / Gholizadeh‐Moghaddam, Mahsa; Ghasemi‐Tehrani, Hatav; Askari, Gholamreza et al.
In: Health Science Reports, Vol. 6, No. 1, e1013, 01.2023.

Research output: Contribution to journal › Article › peer-review

Gholizadeh‐Moghaddam, M, Ghasemi‐Tehrani, H, Askari, G, Jaripur, M, Clark, CCT & Rouhani, MH 2023, 'Effect of magnesium supplementation in improving hyperandrogenism, hirsutism, and sleep quality in women with polycystic ovary syndrome: A randomized, placebo‐controlled clinical trial', Health Science Reports, vol. 6, no. 1, e1013. https://doi.org/10.1002/hsr2.1013

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abstract = "Background and Aims: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women, which causes numerous symptoms in women. The relationship of many micronutrients with this syndrome has been investigated. This study was conducted to examine the effects of magnesium supplementation on hyperandrogenism, hirsutism, and sleep quality in women with PCOS. Methods: In this parallel randomized clinical trial, 64 women with PCOS were randomly assigned to the magnesium group (n = 32) or placebo group (n = 32) for 10 weeks. Patients in the magnesium group received one 250 mg magnesium oxide tablet, per day. Hyperandrogenism, hirsutism, and sleep quality were measured at the beginning and end of the study. This randomized clinical trial was registered at https://www.IRCT.ir (IRCT20130903014551N8). Results: Magnesium supplementation had no significant effect on hyperandrogenism (p = 0.51 for dehydroepiandrosterone sulfates, p = 0.27 for testosterone), hirsutism (p = 0.23), and sleep quality (p = 0.85) compared with placebo. Conclusions: The present study showed that a single dose of magnesium supplementation elicited no beneficial effects on the mentioned symptoms in polycystic women. It is possible that the positive effects of magnesium observed in the former studies were due to the synergistic effects of other vitamins or minerals. More studies are needed in this area.",

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