Low arterial oxygen saturation (SaO2) will result in a reduced rate of arterial oxygen delivery to the tissues (DO2), unless there is a compensatory increase in cardiac output (CO) or haemoglobin concentration (Hb). An adequate DO2 can therefore be maintained by increasing ventilation, CO, or both. Sustaining a tissue specific oxygen extraction is thought to play an important part in overall compensation. The present study has examined responses to acute hypoxic exposure in 8 volunteers (breathing 12% oxygen, balance nitrogen) and describes changes in CO, ventilation and the SaO2. Aims included: examination of the extent of intersubject variations and seeing whether DO2 was maintained. SaO2, PCO2, respiration (via stethograph) and Finapress (non-invasive) arterial blood pressure (BP) were recorded, firstly on air and then on 12% oxygen. CO was derived, off-line, from the BP record. CO was increased in 5 subjects (22%-45%) but was virtually unchanged in 3, and yet comparison for all 8 subjects showed that DO2 on 12% oxygen was not significantly different from DO2 on air (mean on air 1017 ml. min–1; hypoxia 1080 ml. min–1, p = 0.27). SaO2 on 12% oxygen ranged between 85% and 93%. In conclusion, exposure to the same hypoxic gas mixture resulted in differing individual ventilatory and CO responses. However, DO2 was well maintained.
|Title of host publication||Oxygen Transport to Tissue XXXII|
|Editors||Joseph C. LaManna, Michelle A. Puchowicz, Kui Xu, David K Harrison, Duane F. Bruley|
|Place of Publication||US|
|ISBN (Print)||978-1-4419-7755-7, 978-1-4419-7756-4|
|Publication status||Published - 2011|
Bibliographical noteThe full text is not available on the repository.
Bell, M., Thake, C. D., & Wolff, C. B. (2011). Effect of Inspiration of 12%O2 (Balance N2) on Cardiac Output, Respiration, Oxygen Saturation, and Oxygen Delivery. In J. C. LaManna, M. A. Puchowicz, K. Xu, D. K. Harrison, & D. F. Bruley (Eds.), Oxygen Transport to Tissue XXXII (Vol. 701, pp. 327-332). US: Springer Verlag. https://doi.org/10.1007/978-1-4419-7756-4_44