Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials

Thirunavukkarasu Sathish; Kamlesh Khunti; K M Venkat Narayan; Viswanathan Mohan; Melanie J Davies; Thomas Yates; Brian Oldenburg; Kavumpurathu R Thankappan; Robyn J Tapp; Ram Bajpai; Ranjit Mohan Anjana; Mary B Weber; Mohammed K Ali; Jonathan E Shaw

doi:10.2337/dc23-0696

Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials

Thirunavukkarasu Sathish, Kamlesh Khunti, K M Venkat Narayan, Viswanathan Mohan, Melanie J Davies, Thomas Yates, Brian Oldenburg, Kavumpurathu R Thankappan, Robyn J Tapp, Ram Bajpai, Ranjit Mohan Anjana, Mary B Weber, Mohammed K Ali, Jonathan E Shaw

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Abstract

OBJECTIVE: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype.

RESEARCH DESIGN AND METHODS: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual-participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach.

RESULTS: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01).

CONCLUSIONS: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.

Original language	English
Pages (from-to)	1903-1907
Number of pages	5
Journal	Diabetes Care
Volume	46
Issue number	11
Early online date	31 Aug 2023
DOIs	https://doi.org/10.2337/dc23-0696
Publication status	Published - 1 Nov 2023

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Keywords

Advanced and Specialized Nursing
Endocrinology, Diabetes and Metabolism
Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc23-0696

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Sathish, T., Khunti, K., Narayan, K. M. V., Mohan, V., Davies, M. J., Yates, T., Oldenburg, B., Thankappan, K. R., Tapp, R. J., Bajpai, R., Anjana, R. M., Weber, M. B., Ali, M. K., & Shaw, J. E. (2023). Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials. Diabetes Care, 46(11), 1903-1907. https://doi.org/10.2337/dc23-0696

Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials. / Sathish, Thirunavukkarasu; Khunti, Kamlesh; Narayan, K M Venkat et al.
In: Diabetes Care, Vol. 46, No. 11, 01.11.2023, p. 1903-1907.

Research output: Contribution to journal › Article › peer-review

Sathish, T, Khunti, K, Narayan, KMV, Mohan, V, Davies, MJ, Yates, T, Oldenburg, B, Thankappan, KR, Tapp, RJ, Bajpai, R, Anjana, RM, Weber, MB, Ali, MK & Shaw, JE 2023, 'Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials', Diabetes Care, vol. 46, no. 11, pp. 1903-1907. https://doi.org/10.2337/dc23-0696

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abstract = "OBJECTIVE: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype.RESEARCH DESIGN AND METHODS: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual-participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach.RESULTS: Four trials with 2,794 participants (mean age 53.0 years, 60.7\% men) were included: 1,240 (44.4\%), 796 (28.5\%), and 758 (27.1\%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95\% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01).CONCLUSIONS: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.",

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author = "Thirunavukkarasu Sathish and Kamlesh Khunti and Narayan, \{K M Venkat\} and Viswanathan Mohan and Davies, \{Melanie J\} and Thomas Yates and Brian Oldenburg and Thankappan, \{Kavumpurathu R\} and Tapp, \{Robyn J\} and Ram Bajpai and Anjana, \{Ranjit Mohan\} and Weber, \{Mary B\} and Ali, \{Mohammed K\} and Shaw, \{Jonathan E\}",

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AU - Khunti, Kamlesh

AU - Narayan, K M Venkat

AU - Mohan, Viswanathan

AU - Davies, Melanie J

AU - Yates, Thomas

AU - Oldenburg, Brian

AU - Thankappan, Kavumpurathu R

AU - Tapp, Robyn J

AU - Bajpai, Ram

AU - Anjana, Ranjit Mohan

AU - Weber, Mary B

AU - Ali, Mohammed K

AU - Shaw, Jonathan E

N1 - Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

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N2 - OBJECTIVE: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype.RESEARCH DESIGN AND METHODS: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual-participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach.RESULTS: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01).CONCLUSIONS: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.

AB - OBJECTIVE: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype.RESEARCH DESIGN AND METHODS: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual-participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach.RESULTS: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01).CONCLUSIONS: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.

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KW - Endocrinology, Diabetes and Metabolism

KW - Internal Medicine

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Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials

Abstract

Bibliographical note

Keywords

UN SDGs

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