Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials

Thirunavukkarasu Sathish, Kamlesh Khunti, K M Venkat Narayan, Viswanathan Mohan, Melanie J Davies, Thomas Yates, Brian Oldenburg, Kavumpurathu R Thankappan, Robyn J Tapp, Ram Bajpai, Ranjit Mohan Anjana, Mary B Weber, Mohammed K Ali, Jonathan E Shaw

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Abstract

OBJECTIVE: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype.

RESEARCH DESIGN AND METHODS: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual-participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach.

RESULTS: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01).

CONCLUSIONS: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.

Original languageEnglish
Pages (from-to)1903-1907
Number of pages5
JournalDiabetes Care
Volume46
Issue number11
Early online date31 Aug 2023
DOIs
Publication statusPublished - 1 Nov 2023

Bibliographical note

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This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it.

Keywords

  • Advanced and Specialized Nursing
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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