Effect of brief ambient cooling on serum stress biomarkers in older adults during a daylong heat exposure: a laboratory-based heat wave simulation

Ben J Lee; Robert D Meade; Sarah L Davey; Charles D Thake; James J McCormick; Kelli E King; Glen P Kenny

doi:10.1139/apnm-2024-0476

Effect of brief ambient cooling on serum stress biomarkers in older adults during a daylong heat exposure: a laboratory-based heat wave simulation

Ben J Lee
, Robert D Meade
, Sarah L Davey
, Charles D Thake
, James J McCormick
, Kelli E King
, Glen P Kenny

University of Ottawa

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

9 Downloads (Pure)

Abstract

Visiting an air-conditioned location during heat exposure reduces physiological strain; however, the effects on gastrointestinal barrier dysfunction and renal ischemia remain unexplored. We compared serum protein responses during a 9 h heat exposure (40.3 °C, 9.3% relative humidity) in 17 older adults without cooling (control) and 19 older adults with a cooling break (∼23 °C) during hours 5 and 6 (cooling). IFABP and sCD14 increased similarly across groups. NGAL was 3.2 pg/mL [1.9, 6.1] lower in the cooling group during heat exposure. A 2 h cooling centre exposure did not ameliorate gastrointestinal barrier dysfunction, but did a reduce a surrogate marker of renal ischemia. ClinicalTrials.gov identifier: NCT04353076.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Applied Physiology, Nutrition, and Metabolism
Volume	50
DOIs	https://doi.org/10.1139/apnm-2024-0476
Publication status	Published - 11 Apr 2025

Bibliographical note

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it

Funding

This research was funded by the Canadian Institutes for Health Research (grant 399434, PJT-180242) and Health Canada (contract 4500387992; funds held by GPK). The funders had no role in trial design, collection, analysis, or interpretation of data, or in manuscript development. No authors received direct compensation related to the development of this article. RDM was supported by the Canadian Institutes of Health Research and the Human and Environmental Physiology Research Unit. JJM and KEK were supported by Mitacs Accelerate and the Human and Environmental Physiology Research Unit.

Funders	Funder number
Human and Environmental Physiology Research Unit
Mitacs
Canadian Institutes of Health Research	PJT-180242, 399434
Canadian Institutes of Health Research
Health Canada	4500387992

Keywords

Aged
Aged, 80 and over
Female
Humans
Male
Biomarkers/blood
Blood Proteins/metabolism
Cold Temperature
Hot Temperature/adverse effects
Lipocalin-2/blood
Stress, Physiological

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10.1139/apnm-2024-0476

Lee2025AAMAccepted author manuscript, 442 KB

Cite this

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title = "Effect of brief ambient cooling on serum stress biomarkers in older adults during a daylong heat exposure: a laboratory-based heat wave simulation",

abstract = "Visiting an air-conditioned location during heat exposure reduces physiological strain; however, the effects on gastrointestinal barrier dysfunction and renal ischemia remain unexplored. We compared serum protein responses during a 9 h heat exposure (40.3 °C, 9.3\% relative humidity) in 17 older adults without cooling (control) and 19 older adults with a cooling break (∼23 °C) during hours 5 and 6 (cooling). IFABP and sCD14 increased similarly across groups. NGAL was 3.2 pg/mL [1.9, 6.1] lower in the cooling group during heat exposure. A 2 h cooling centre exposure did not ameliorate gastrointestinal barrier dysfunction, but did a reduce a surrogate marker of renal ischemia. ClinicalTrials.gov identifier: NCT04353076.",

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ER -

Effect of brief ambient cooling on serum stress biomarkers in older adults during a daylong heat exposure: a laboratory-based heat wave simulation

Abstract

Bibliographical note

Funding

Keywords

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