Effect of a Peer-led Lifestyle Intervention on Individuals With Normal Weight Obesity: Insights From the Kerala Diabetes Prevention Program

Nitin Kapoor, Mojtaba Lotfaliany, Thirunavukkarasu Sathish, Kavumpurathu R. Thankappan, Robyn J. Tapp, Nihal Thomas, John Furler, Brian Oldenburg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Normal weight obesity (NWO) is a unique phenotype of obesity associated with high cardiovascular mortality. There is limited literature on assessing the effect of therapeutic interventions on the cardiometabolic health of these individuals. We studied the effect of a peer-led lifestyle intervention on key cardiometabolic parameters (blood glucose, blood pressure, and plasma lipids) in individuals with NWO. Methods: This study is a secondary data analysis of the Kerala Diabetes Prevention Program, a cluster-randomized controlled study that involves a peer-led, real-life lifestyle intervention for individuals from the community between the ages of 30 and 60 years with a high diabetes risk. Participants underwent a rigorous cardiometabolic evaluation at baseline and at 2-year follow-up. Findings: A total of 292 recruited individuals with NWO were randomized into the intervention (n = 159) and control (n = 133) arms. At 2 years of follow-up, there was minimal but statistically significant improvement in systolic blood pressure and serum HDL level in the intervention arm, but no statistical difference was seen in other lipid and glycemic parameters. Implications: This study provides early evidence of the effect of a lifestyle intervention in a cohort of individuals with NWO. Only systolic blood pressure and serum HDL level had a mild favorable change in the intervention arm when compared with the control arm.

Original languageEnglish
Pages (from-to)1618-1624
Number of pages7
JournalClinical Therapeutics
Volume42
Issue number8
DOIs
Publication statusPublished - 25 Jul 2020

Keywords

  • lifestyle intervention
  • normal weight obesity
  • South Asian phenotype
  • thin-fat phenotype

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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