ECG imaging of ventricular tachycardia: evaluation against simultaneous non-contact mapping and CMR-derived grey zone

Walther H W Schulze, Zhong Chen, Jatin Relan, Danila Potyagaylo, Martin W Krueger, Rashed Karim, Manav Sohal, Anoop Shetty, YingLiang Ma, Nicholas Ayache, Maxime Sermesant, Herve Delingette, Julian Bostock, Reza Razavi, Kawal S Rhode, Christopher A Rinaldi, Olaf Dössel

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Abstract

ECG imaging is an emerging technology for the reconstruction of cardiac electric activity from non-invasively measured body surface potential maps. In this case report, we present the first evaluation of transmurally imaged activation times against endocardially reconstructed isochrones for a case of sustained monomorphic ventricular tachycardia (VT). Computer models of the thorax and whole heart were produced from MR images. A recently published approach was applied to facilitate electrode localization in the catheter laboratory, which allows for the acquisition of body surface potential maps while performing non-contact mapping for the reconstruction of local activation times. ECG imaging was then realized using Tikhonov regularization with spatio-temporal smoothing as proposed by Huiskamp and Greensite and further with the spline-based approach by Erem et al. Activation times were computed from transmurally reconstructed transmembrane voltages. The results showed good qualitative agreement between the non-invasively and invasively reconstructed activation times. Also, low amplitudes in the imaged transmembrane voltages were found to correlate with volumes of scar and grey zone in delayed gadolinium enhancement cardiac MR. The study underlines the ability of ECG imaging to produce activation times of ventricular electric activity-and to represent effects of scar tissue in the imaged transmembrane voltages.

Original languageEnglish
Pages (from-to)979-990
Number of pages12
JournalMedical & biological engineering & computing
Volume55
Issue number6
Early online date20 Sep 2016
DOIs
Publication statusPublished - Jun 2017
Externally publishedYes

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Electrocardiography
Chemical activation
Imaging techniques
Surface potential
Electric potential
Catheters
Gadolinium
Splines
Tissue
Electrodes

Keywords

  • Inverse problem of ECG
  • Clinical validation
  • Ventricular tachycardia
  • Non-contact mapping
  • ECG imaging

Cite this

ECG imaging of ventricular tachycardia : evaluation against simultaneous non-contact mapping and CMR-derived grey zone. / Schulze, Walther H W; Chen, Zhong; Relan, Jatin; Potyagaylo, Danila; Krueger, Martin W; Karim, Rashed; Sohal, Manav; Shetty, Anoop; Ma, YingLiang; Ayache, Nicholas; Sermesant, Maxime; Delingette, Herve; Bostock, Julian; Razavi, Reza; Rhode, Kawal S; Rinaldi, Christopher A; Dössel, Olaf.

In: Medical & biological engineering & computing, Vol. 55, No. 6, 06.2017, p. 979-990.

Research output: Contribution to journalArticle

Schulze, WHW, Chen, Z, Relan, J, Potyagaylo, D, Krueger, MW, Karim, R, Sohal, M, Shetty, A, Ma, Y, Ayache, N, Sermesant, M, Delingette, H, Bostock, J, Razavi, R, Rhode, KS, Rinaldi, CA & Dössel, O 2017, 'ECG imaging of ventricular tachycardia: evaluation against simultaneous non-contact mapping and CMR-derived grey zone' Medical & biological engineering & computing, vol. 55, no. 6, pp. 979-990. https://doi.org/10.1007/s11517-016-1566-x
Schulze, Walther H W ; Chen, Zhong ; Relan, Jatin ; Potyagaylo, Danila ; Krueger, Martin W ; Karim, Rashed ; Sohal, Manav ; Shetty, Anoop ; Ma, YingLiang ; Ayache, Nicholas ; Sermesant, Maxime ; Delingette, Herve ; Bostock, Julian ; Razavi, Reza ; Rhode, Kawal S ; Rinaldi, Christopher A ; Dössel, Olaf. / ECG imaging of ventricular tachycardia : evaluation against simultaneous non-contact mapping and CMR-derived grey zone. In: Medical & biological engineering & computing. 2017 ; Vol. 55, No. 6. pp. 979-990.
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