Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza

Richard Aspinall, Sheila Govind, Antonio Lapenna, Pierre Olivier Lang

Research output: Contribution to journalArticle

4 Citations (Scopus)
4 Downloads (Pure)

Abstract

Transfusion of autologous leukocytes after prolonged storage has been proposed as a means of rejuvenating the immune system of older individuals. The rationale for this approach is that age related immune decline is associated with a diminished pool of naïve T cells following atrophy of the thymus and reduction in thymic output. The presence of high levels of naïve T cells within the blood of young individuals could provide a boost to the immune system of an older " self" through a rejuvenation of the naïve T cell pool. However what remains unresolved is whether the cells could be incorporated effectively into the T cell pool of the host and whether effectors could be generated. Using CD45 congenic mice in our experiments we show that the transfusion of young donor cells into older congenic host animals leads to their successful incorporation into the peripheral T cell pool. When the recipients were challenged with influenza virus, specific effector CD8 cells were generated which were of both host and donor origin. We found no relationship between the number of responder cells of donor origin at the time of assay and the number of cells injected.

Original languageEnglish
Article number34
JournalImmunity and Ageing
Volume10
Issue number1
DOIs
Publication statusPublished - 16 Aug 2013
Externally publishedYes

Fingerprint

Human Influenza
Lymphocytes
T-Lymphocytes
Congenic Animals
Immune System
Leukocyte Transfusion
Cell Count
Congenic Mice
Rejuvenation
Orthomyxoviridae
Thymus Gland
Atrophy

Keywords

  • CD8 T cell
  • Influenza virus
  • Transfusion

ASJC Scopus subject areas

  • Immunology
  • Ageing

Cite this

Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza. / Aspinall, Richard; Govind, Sheila; Lapenna, Antonio; Lang, Pierre Olivier.

In: Immunity and Ageing, Vol. 10, No. 1, 34, 16.08.2013.

Research output: Contribution to journalArticle

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