Does vitamin C supplementation exert profitable effects on serum lipid profile in patients with type 2 diabetes?: A systematic review and dose-response meta-analysis

Zahra Namkhah; Damoon Ashtary-Larky; Fatemeh Naeini; Cain C T Clark; Omid Asbaghi

doi:10.1016/j.phrs.2021.105665

Does vitamin C supplementation exert profitable effects on serum lipid profile in patients with type 2 diabetes? A systematic review and dose-response meta-analysis

Zahra Namkhah, Damoon Ashtary-Larky, Fatemeh Naeini, Cain C T Clark, Omid Asbaghi

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

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Abstract

Previous studies have reported that vitamin C supplementation may decrease lipid profile in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the influence of vitamin C supplementation on lipid profile in patients with T2DM. Studies examining the effects of vitamin C supplementation on lipid profile in patients with T2DM, published up to November 2020, were identified through PubMed, SCOPUS, and Embase databases. 15 studies, including 872 participants, were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI). Findings from 15 studies indicated that vitamin C supplementation significantly decreased Triglyceride (TG) (WMD: -16.48mg/dl, 95% CI (-31.89, -1.08), P <0.001) and total cholesterol (TC) (WMD: -13.00mg/dl, 95% CI (-23.10, -2.91), P <0.001) in patients with T2DM. However, vitamin C supplementation failed to improve LDL and HDL. The meta-regression analysis suggested that lipid profile improvement was affected by duration of vitamin C treatment. Dose-response analysis showed that vitamin C supplementation changed LDL significantly based on vitamin C dose. According to our findings, vitamin C supplementation significantly improved lipid profile via decreases in TG and TC. However, vitamin C failed to affect LDL and HDL in diabetic populations. It appears that vitamin C supplementation is more beneficial to lipid profile in long-term vs. short term interventions.

Original language	English
Article number	105665
Number of pages	13
Journal	Pharmacological Research
Volume	169
Early online date	11 May 2021
DOIs	https://doi.org/10.1016/j.phrs.2021.105665
Publication status	Published - Jul 2021

Bibliographical note

© 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders.

This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it

Keywords

Lipid profile
Dyslipidemia
Diabetes
Vitamin C
Meta-analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.phrs.2021.105665

Post-PrintAccepted author manuscript, 960 KBLicence: CC BY-NC-ND

Cite this

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title = "Does vitamin C supplementation exert profitable effects on serum lipid profile in patients with type 2 diabetes?: A systematic review and dose-response meta-analysis",

abstract = "Previous studies have reported that vitamin C supplementation may decrease lipid profile in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the influence of vitamin C supplementation on lipid profile in patients with T2DM. Studies examining the effects of vitamin C supplementation on lipid profile in patients with T2DM, published up to November 2020, were identified through PubMed, SCOPUS, and Embase databases. 15 studies, including 872 participants, were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI). Findings from 15 studies indicated that vitamin C supplementation significantly decreased Triglyceride (TG) (WMD: -16.48mg/dl, 95% CI (-31.89, -1.08), P <0.001) and total cholesterol (TC) (WMD: -13.00mg/dl, 95% CI (-23.10, -2.91), P <0.001) in patients with T2DM. However, vitamin C supplementation failed to improve LDL and HDL. The meta-regression analysis suggested that lipid profile improvement was affected by duration of vitamin C treatment. Dose-response analysis showed that vitamin C supplementation changed LDL significantly based on vitamin C dose. According to our findings, vitamin C supplementation significantly improved lipid profile via decreases in TG and TC. However, vitamin C failed to affect LDL and HDL in diabetic populations. It appears that vitamin C supplementation is more beneficial to lipid profile in long-term vs. short term interventions.",

keywords = "Lipid profile, Dyslipidemia, Diabetes, Vitamin C, Meta-analysis",

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AU - Naeini, Fatemeh

AU - Clark, Cain C T

AU - Asbaghi, Omid

N1 - © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. This document is the author’s post-print version, incorporating any revisions agreed during the peer-review process. Some differences between the published version and this version may remain and you are advised to consult the published version if you wish to cite from it

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