Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes

Hayley Crawford, J. Waite, C. Oliver

    Research output: Research - peer-reviewArticle

    • 2 Citations

    Abstract

    Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
    LanguageEnglish
    Pages3728-3740
    Number of pages13
    JournalJournal of Autism and Developmental Disorders
    Volume47
    Issue number12
    DOIs
    StatePublished - 31 Jan 2017

    Fingerprint

    Rubinstein-Taybi Syndrome
    Agoraphobia
    Panic
    Anxiety Disorders
    Anxiety
    Fear
    Separation Anxiety
    Wounds and Injuries
    Intellectual Disability

    Bibliographical note

    This article has been accepted for publication in the Journal of Autism and Developmental Disorders. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

    Keywords

    • Anxiety
    • genetic syndromes
    • fragile X syndrome
    • Cornelia de Lange syndrome
    • Rubinstein-Taybi syndrome
    • intellectual disability

    Cite this

    Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes. / Crawford, Hayley; Waite, J.; Oliver, C.

    In: Journal of Autism and Developmental Disorders, Vol. 47, No. 12, 31.01.2017, p. 3728-3740.

    Research output: Research - peer-reviewArticle

    @article{51d39078f8ad4c40942d46e73d8dc165,
    title = "Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes",
    abstract = "Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.",
    keywords = "Anxiety, genetic syndromes, fragile X syndrome, Cornelia de Lange syndrome, Rubinstein-Taybi syndrome, intellectual disability",
    author = "Hayley Crawford and J. Waite and C. Oliver",
    note = "This article has been accepted for publication in the Journal of Autism and Developmental Disorders. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.",
    year = "2017",
    month = "1",
    doi = "10.1007/s10803-016-3015-y",
    volume = "47",
    pages = "3728--3740",
    journal = "Journal of Autism and Developmental Disorders",
    issn = "0162-3257",
    publisher = "Springer Verlag",
    number = "12",

    }

    TY - JOUR

    T1 - Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes

    AU - Crawford,Hayley

    AU - Waite,J.

    AU - Oliver,C.

    N1 - This article has been accepted for publication in the Journal of Autism and Developmental Disorders. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

    PY - 2017/1/31

    Y1 - 2017/1/31

    N2 - Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.

    AB - Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.

    KW - Anxiety

    KW - genetic syndromes

    KW - fragile X syndrome

    KW - Cornelia de Lange syndrome

    KW - Rubinstein-Taybi syndrome

    KW - intellectual disability

    UR - http://www.springer.com/psychology/child+%26+school+psychology/journal/10803

    U2 - 10.1007/s10803-016-3015-y

    DO - 10.1007/s10803-016-3015-y

    M3 - Article

    VL - 47

    SP - 3728

    EP - 3740

    JO - Journal of Autism and Developmental Disorders

    T2 - Journal of Autism and Developmental Disorders

    JF - Journal of Autism and Developmental Disorders

    SN - 0162-3257

    IS - 12

    ER -