Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
Bibliographical noteThis article has been accepted for publication in the Journal of Autism and Developmental Disorders.
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- genetic syndromes
- fragile X syndrome
- Cornelia de Lange syndrome
- Rubinstein-Taybi syndrome
- intellectual disability
Crawford, H., Waite, J., & Oliver, C. (2017). Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes. Journal of Autism and Developmental Disorders, 47(12), 3728-3740. https://doi.org/10.1007/s10803-016-3015-y