Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes

Hayley Crawford, J. Waite, C. Oliver

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    34 Citations (Scopus)
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    Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
    Original languageEnglish
    Pages (from-to)3728-3740
    Number of pages13
    JournalJournal of Autism and Developmental Disorders
    Issue number12
    Early online date31 Jan 2017
    Publication statusPublished - Dec 2017

    Bibliographical note

    This article has been accepted for publication in the Journal of Autism and Developmental Disorders.
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    Creative Commons Attribution 4.0 International License (http://
    creativecommons.org/licenses/by/4.0/), which permits unrestricted
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    • Anxiety
    • genetic syndromes
    • fragile X syndrome
    • Cornelia de Lange syndrome
    • Rubinstein-Taybi syndrome
    • intellectual disability


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