Diverse profiles of anxiety related disorders in fragile X, Cornelia de Lange and Rubinstein-Taybi syndromes

Hayley Crawford, J. Waite, C. Oliver

    Research output: Contribution to journalArticle

    10 Citations (Scopus)
    42 Downloads (Pure)

    Abstract

    Anxiety disorders are heightened in specific genetic syndromes in comparison to intellectual disability of heterogeneous etiology. In this study we described and contrasted anxiety symptomatology in fragile X (FXS), Cornelia de Lange (CdLS) and Rubinstein-Taybi syndromes (RTS), and compared the symptomatology to normative data for typically-developing children and children diagnosed with an anxiety disorder. Scores did not differ between children diagnosed with an anxiety disorder and: a) participants with FXS on social phobia, panic/agoraphobia, physical injury fears, and obsessive-compulsive subscales, b) participants with CdLS on separation anxiety, generalized anxiety, panic/agoraphobia, physical injury fears and obsessive-compulsive subscales, and c) participants with RTS on panic/agoraphobia and obsessive-compulsive subscales. The results highlight divergent profiles of anxiety symptomatology between these groups.
    Original languageEnglish
    Pages (from-to)3728-3740
    Number of pages13
    JournalJournal of Autism and Developmental Disorders
    Volume47
    Issue number12
    Early online date31 Jan 2017
    DOIs
    Publication statusPublished - Dec 2017

    Bibliographical note

    This article has been accepted for publication in the Journal of Autism and Developmental Disorders.
    This article is distributed under the terms of the
    Creative Commons Attribution 4.0 International License (http://
    creativecommons.org/licenses/by/4.0/), which permits unrestricted
    use, distribution, and reproduction in any medium, provided you give
    appropriate credit to the original author(s) and the source, provide a
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    Keywords

    • Anxiety
    • genetic syndromes
    • fragile X syndrome
    • Cornelia de Lange syndrome
    • Rubinstein-Taybi syndrome
    • intellectual disability

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