Direct functional connectivity between the thalamus (Vim) and the contralateral motor cortex: Just a single case observation or a common pathway in the human brain?

Ptolemaios G. Sarrigiannis, Yifan Zhao, Fei He, Hualiang Wei, Stephen A. Billings, Sarah Lawrence, Jeremy Rowe, Charles Romanowski, Nigel Hoggard, Dasappaiah Ganesh Rao, Richard Grünewald, Aijaz Khan, Marios Hadjivassilliou, John Yianni

Research output: Contribution to journalLetter

2 Citations (Scopus)


In this case report we present in vivo evidence of direct bilateral cortico-thalamic connectivity on a patient with fragile-x tremor ataxia syndrome who underwent deep brain stimulation (DBS) surgery for bilateral severe rest and kinetic tremor. We use very short latency cortical evoked responses (CER) as evidence of a direct anatomical pathway between the thalamus and the ipsilateral and contralateral cortex. CERs with various latencies have been previously reported from patients undergoing DBS for intractable tremor and from experimental models in primates [1], [2], [3], [4].
Original languageEnglish
Pages (from-to)1230-1233
Number of pages4
JournalBrain Stimulation
Issue number6
Early online date18 Aug 2015
Publication statusPublished - 1 Nov 2015
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)
  • Biophysics
  • Clinical Neurology

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